Hs02970477_cn

• Gene Symbol: MAP3K15
• Assay Reference Genome Location: Chr.X:19360537 on build GRCh38
• Cytoband: Xp22.12

Target Gene Details

• Entrez Gene ID: 389840
• Gene Name: mitogen-activated protein kinase kinase kinase 15
• Gene Aliases: ASK3, bA723P2.3
• Location: Chr.X:19360058-19515459 on Build GRCh38
• Assay Gene Location: Within Exon 32

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAP3K15	NM_001001671.3	29	4154	NP_001001671.3
	XM_011545507.2	30	4381	XP_011543809.2
	XM_011545508.2	30	4294	XP_011543810.2
	XM_011545510.2	23	4894	XP_011543812.1
	XM_011545511.2	20	3405	XP_011543813.1
	AK122632.1	8	1572
	AK131412.1	26	3482	BAD18559.1
	AK131477.1	30	4214	BAD18622.1

Target Gene Details

• Entrez Gene ID: 5160
• Gene Name: pyruvate dehydrogenase (lipoamide) alpha 1
• Gene Aliases: PDHA, PDHAD, PDHCE1A, PHE1A
• Location: Chr.X:19343893-19361707 on Build GRCh38
• Assay Gene Location: Within Exon 12

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PDHA1	NM_000284.3	11	2202	NP_000275.1
	NM_001173454.1	12	2316	NP_001166925.1
	NM_001173455.1	11	2223	NP_001166926.1
	NM_001173456.1	10	2109	NP_001166927.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3573627	Chr.X:19351701 - 19362562 on Build GRCh38	Loss	MAP3K15 PDHA1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase, dehydrogenase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
glucose metabolic process
acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
tricarboxylic acid cycle
regulation of acetyl-CoA biosynthetic process from pyruvate
glyoxylate metabolic process
mitochondrial acetyl-CoA biosynthetic process from pyruvate

Function(s)

MAP kinase kinase kinase activity
ATP binding
metal ion binding
pyruvate dehydrogenase activity
pyruvate dehydrogenase (acetyl-transferring) activity
pyruvate dehydrogenase (NAD+) activity