Hs03337812_cn

• Gene Symbol: TP73
• Assay Reference Genome Location: Chr.1:3662163 on build GRCh38
• Cytoband: 1p36.32

Target Gene Details

• Entrez Gene ID: 7161
• Gene Name: tumor protein p73
• Gene Aliases: P73
• Location: Chr.1:3652565-3736201 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TP73	NM_001204184.1			NP_001191113.1
	NM_001204185.1			NP_001191114.1
	NM_001204186.1			NP_001191115.1
	NM_001204187.1			NP_001191116.1
	NM_001204188.1			NP_001191117.1
	NM_005427.3			NP_005418.1
	BC117251.1
	BC117253.1
	Y11416.1			CAA72220.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470687	Chr.1:3356499 - 3763210 on Build GRCh38	Loss	TP73 CCDC27 TP73-AS1 MEGF6 MIR551A ARHGEF16 WRAP73 PRDM16 TPRG1L
nsv410	Chr.1:3635087 - 3667080 on Build GRCh38	Insertion	TP73 WRAP73
nsv1012423	Chr.1:3477686 - 4747449 on Build GRCh38	Gain	CEP104 CCDC27 DFFB TP73-AS1 LRRC47 SMIM1 C1orf174 LOC284661 TPRG1L TP73 AJAP1 LINC01346 MEGF6 MIR551A ARHGEF16 LINC01134 WRAP73
esv3585042	Chr.1:3585575 - 4260083 on Build GRCh38	Gain	CEP104 CCDC27 DFFB TP73-AS1 LRRC47 SMIM1 C1orf174 TPRG1L TP73 LINC01346 MEGF6 LINC01134 WRAP73
nsv1001715	Chr.1:3627619 - 3769754 on Build GRCh38	Loss	TP73 CCDC27 TP73-AS1 WRAP73 TPRG1L
nsv545128	Chr.1:3630371 - 3700037 on Build GRCh38	Loss	TP73 WRAP73
nsv951959	Chr.1:3051037 - 3812036 on Build GRCh38	Deletion	CCDC27 TP73-AS1 LRRC47 SMIM1 MIR4251 LINC00982 TPRG1L TP73 MEGF6 LOC105378604 MIR551A ARHGEF16 WRAP73 PRDM16
nsv830314	Chr.1:3660776 - 3804275 on Build GRCh38	Gain+Loss	TP73 CCDC27 TP73-AS1 LRRC47 SMIM1
esv3585045	Chr.1:3611161 - 3686920 on Build GRCh38	Gain	TP73 MEGF6 WRAP73 TPRG1L

More Information

Additional Information:

For this assay, SNP(s) [rs116527216] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

P53-like transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
kidney development
mismatch repair
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle arrest
regulation of mitotic cell cycle
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to organonitrogen compound
response to gamma radiation
regulation of gene expression
viral process
mitotic G1 DNA damage checkpoint
cellular response to UV
response to drug
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
negative regulation of JUN kinase activity
negative regulation of neuron apoptotic process
negative regulation of neuron differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of oligodendrocyte differentiation
protein tetramerization
negative regulation of cardiac muscle cell proliferation
positive regulation of cell cycle arrest
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of signal transduction by p53 class mediator

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
chromatin binding
damaged DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
protein kinase binding
identical protein binding
transcription regulatory region DNA binding
metal ion binding