Hs03354625_cn

• Gene Symbol: CHRM3
• Assay Reference Genome Location: Chr.1:239707602 on build GRCh38
• Cytoband: 1q43

Target Gene Details

• Entrez Gene ID: 1131
• Gene Name: cholinergic receptor muscarinic 3
• Gene Aliases: EGBRS, HM3, PBS
• Location: Chr.1:239386565-239915450 on Build GRCh38
• Assay Gene Location: Within Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CHRM3	NM_000740.2			NP_000731.1
	XM_005273032.3			XP_005273089.1
	XM_011544041.2			XP_011542343.1
	XM_011544043.2			XP_011542345.1
	XM_011544044.2			XP_011542346.1
	XM_011544045.2			XP_011542347.1
	XM_011544046.2			XP_011542348.1
	XM_011544047.2			XP_011542349.1
	XM_017000152.1			XP_016855641.1
	XM_017000153.1			XP_016855642.1
	XM_017000154.1			XP_016855643.1
	XM_017000155.1			XP_016855644.1
	XM_017000156.1			XP_016855645.1
	XM_017000157.1			XP_016855646.1
	XM_017000158.1			XP_016855647.1
	XM_017000159.1			XP_016855648.1
	XM_017000160.1			XP_016855649.1
	XM_017000161.1			XP_016855650.1
	XM_017000162.1			XP_016855651.1
	AF279779.1			AAG30036.1
	AK056349.1

Target Gene Details

• Entrez Gene ID: 100506915
• Gene Name: CHRM3 antisense RNA 2
• Gene Aliases: -
• Location: Chr.1:239707126-239719119 on Build GRCh38
• Assay Gene Location: Within Exon 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CHRM3-AS2	NR_103776.1	3	417
	AL832284.1	3	364
	CT002712.1	3	417

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv549435	Chr.1:239211710 - 239810706 on Build GRCh38	Gain	CHRM3 LOC107983951 CHRM3-AS2
esv2759009	Chr.1:239602794 - 240226204 on Build GRCh38	Gain	CHRM3 RPS7P5 FMN2 CHRM3-AS2 CHRM3-AS1

More Information

Additional Information:

For this assay, SNP(s) [rs75804766] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

G-protein coupled receptor

Gene Ontology Categories:

Process(es)

regulation of vascular smooth muscle contraction
cellular protein modification process
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
cell proliferation
positive regulation of smooth muscle contraction
saliva secretion

Function(s)

phosphatidylinositol phospholipase C activity
receptor activity
protein binding
drug binding
G-protein coupled acetylcholine receptor activity
acetylcholine binding