Hs03356870_cn

• Gene Symbol: LOC100506504
• Assay Reference Genome Location: Chr.1:2182082 on build GRCh38
• Cytoband: 1p36.33

Target Gene Details

• Entrez Gene ID: 100506504
• Gene Name: uncharacterized LOC100506504
• Gene Aliases: -
• Location: Chr.1:2181811-2184176 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC100506504	XM_011542503.2	2	1266	XP_011540805.1

Target Gene Details

• Entrez Gene ID: 5590
• Gene Name: protein kinase C zeta
• Gene Aliases: PKC-ZETA, PKC2
• Location: Chr.1:2050470-2185395 on Build GRCh38
• Assay Gene Location: Within Intron 26

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRKCZ	NM_001033581.1			NP_001028753.1
	NM_001033582.1			NP_001028754.1
	NM_001242874.1			NP_001229803.1
	NM_002744.4			NP_002735.3
	XM_017001790.1			XP_016857279.1
	XM_017001791.1			XP_016857280.1
	XM_017001796.1			XP_016857285.1
	XM_017001798.1			XP_016857287.1
	XM_017001799.1			XP_016857288.1
	XM_017001801.1			XP_016857290.1
	XM_017001804.1			XP_016857293.1
	XM_017001805.1			XP_016857294.1
	AK097627.1
	AK131526.1
	AK290995.1
	AK294649.1
	AK294782.1
	AK302160.1
	BC008058.2			AAH08058.1
	BC014270.2			AAH14270.1
	BT007082.1			AAP35745.1
	L14283.1			AAA36488.1
	Z15108.1			CAA78813.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv461727	Chr.1:2151050 - 2251031 on Build GRCh38	Loss	FAAP20 PRKCZ SKI LOC105378592 LOC100506504
nsv482937	Chr.1:10001 - 2368561 on Build GRCh38	Loss	MIR6808 LOC107984841 TTLL10-AS1 LOC100287934 LOC102724312 LOC105378589 ACAP3 LOC100288175 FAM132A MIB2 HES4 TNFRSF18 MXRA8 AURKAIP1 MMP23A LOC100132287 C1orf159 KLHL17 AGRN TMEM240 TMEM88B LOC102725121 LOC729737 LOC101928626 PRKCZ LOC100130417 LINC01128 LINC01342 LOC100506504 MIR1302-2 DDX11L1 OR4F5 ATAD3A LOC107985729 CDK11B FNDC10 ISG15 ANKRD65 MIR200B PUSL1 SLC35E2 MMP23B LOC107985728 FAAP20 MIR6726 SDF4 LOC148413 MIR6859-2 MIR6723 CDK11A MRPL20 FAM138A PERM1 TMEM52 VWA1 NADK CPSF3L MIR6727 WASH7P CCNL2 LINC00115 CFAP74 CPTP LOC105378592 DVL1 NOC2L LOC100288069 TAS1R3 GNB1 OR4F16 SSU72 ATAD3B SLC35E2B TTLL10 MTND1P23 MIR429 CALML6 MTND2P28 FAM87B LOC100133331 UBE2J2 ATAD3C B3GALT6 LOC105378949 OR4F29 TNFRSF4 SAMD11 MORN1 LOC100129534 MIR200A RNF223 LOC284600 GABRD MIR6859-1 LOC100134822 PLEKHN1 SKI LOC105378948 SCNN1D FAM41C LOC105378591 LOC105378947
nsv951530	Chr.1:2153662 - 2229961 on Build GRCh38	Deletion	FAAP20 PRKCZ SKI LOC105378592 LOC100506504
nsv834557	Chr.1:2117631 - 2311104 on Build GRCh38	Loss	FAAP20 PRKCZ SKI LOC105378592 LOC100506504
nsv470681	Chr.1:2092625 - 2182126 on Build GRCh38	Loss	PRKCZ LOC100506504

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

microtubule cytoskeleton organization
positive regulation of cell-matrix adhesion
protein phosphorylation
inflammatory response
signal transduction
transforming growth factor beta receptor signaling pathway
long-term memory
positive regulation of cell proliferation
insulin receptor signaling pathway
cell migration
peptidyl-serine phosphorylation
establishment of cell polarity
negative regulation of protein complex assembly
actin cytoskeleton reorganization
activation of phospholipase D activity
activation of protein kinase B activity
positive regulation of interleukin-4 production
negative regulation of apoptotic process
positive regulation of T-helper 2 cell differentiation
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
vesicle transport along microtubule
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
negative regulation of hydrolase activity
membrane depolarization
membrane hyperpolarization
long-term synaptic potentiation
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
protein localization to plasma membrane
neuron projection extension
positive regulation of excitatory postsynaptic potential
positive regulation of T-helper 2 cell cytokine production
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
positive regulation of interleukin-10 secretion

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
potassium channel regulator activity
protein kinase binding
protein domain specific binding
phospholipase binding
insulin receptor substrate binding
metal ion binding
14-3-3 protein binding