Hs03385751_cn

• Gene Symbol: CR1
• Assay Reference Genome Location: Chr.1:207598930 on build GRCh38
• Cytoband: 1q32.2

Target Gene Details

• Entrez Gene ID: 1378
• Gene Name: complement component 3b/4b receptor 1 (Knops blood group)
• Gene Aliases: C3BR, C4BR, CD35, KN
• Location: Chr.1:207496128-207641765 on Build GRCh38
• Assay Gene Location: Within Intron 35

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CR1	NM_000573.3			NP_000564.2
	NM_000651.4			NP_000642.3
	XM_006711166.2			XP_006711229.1
	XM_011509205.1			XP_011507507.1
	X05309.1			CAA28933.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3891082	Chr.1:207523372 - 207779899 on Build GRCh38	Loss	CR1L CR1 CD46
esv2675458	Chr.1:207540634 - 207708875 on Build GRCh38	Deletion	CR1L CR1
esv2722106	Chr.1:207502410 - 207681369 on Build GRCh38	Deletion	CR1L CR1
esv2758993	Chr.1:207384550 - 207751722 on Build GRCh38	Gain+Loss	CR1L CR1 CR2
esv3545666	Chr.1:207509399 - 207692876 on Build GRCh38	Deletion	CR1L CR1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

complement receptor mediated signaling pathway
complement activation, classical pathway
regulation of complement activation
innate immune response
negative regulation of complement activation, alternative pathway
negative regulation of complement activation, classical pathway
viral entry into host cell
negative regulation of serine-type endopeptidase activity
positive regulation of serine-type endopeptidase activity

Function(s)

virus receptor activity
complement component C3b binding
complement component C4b binding
complement component C4b receptor activity
complement component C3b receptor activity