Hs03437296_cn

• Gene Symbol: CASP10
• Assay Reference Genome Location: Chr.2:201207031 on build GRCh38
• Cytoband: 2q33.1

Target Gene Details

• Entrez Gene ID: 843
• Gene Name: caspase 10
• Gene Aliases: ALPS2, FLICE2, MCH4
• Location: Chr.2:201182881-201229406 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CASP10	NM_001206524.1			NP_001193453.1
	NM_001206542.1			NP_001193471.1
	NM_001230.4			NP_001221.2
	NM_032974.4			NP_116756.2
	NM_032976.3			NP_116758.1
	NM_032977.3			NP_116759.2
	XM_005246907.2			XP_005246964.1
	XM_006712796.3			XP_006712859.1
	XM_011511990.2			XP_011510292.1
	AF111344.1			AAD28402.1
	AF111345.1			AAD28403.1
	AJ487678.1			CAD32371.1
	AJ487679.1			CAD32372.1
	AK304859.1
	BC042844.1			AAH42844.1
	KU177959.1
	KU177960.1
	U60519.1			AAC50644.1
	U86214.1			AAB46730.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1160898	Chr.2:201196327 - 201213771 on Build GRCh38	Deletion	CASP10
nsv584160	Chr.2:201039216 - 201298760 on Build GRCh38	Loss	CFLAR NDUFB3 CASP8 RPL17P10 ALS2CR12 CFLAR-AS1 FAM126B CASP10
esv3593974	Chr.2:201198802 - 201212212 on Build GRCh38	Loss	CASP10
nsv821874	Chr.2:201200600 - 201210595 on Build GRCh38	Loss	CASP10

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

proteolysis
apoptotic process
cell surface receptor signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
macrophage differentiation
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
apoptotic signaling pathway

Function(s)

cysteine-type endopeptidase activity
protein binding
ubiquitin protein ligase binding
death effector domain binding
cysteine-type endopeptidase activity involved in apoptotic signaling pathway