Hs03520187_cn

• Gene Symbol: LRPAP1
• Assay Reference Genome Location: Chr.4:3513967 on build GRCh38
• Cytoband: 4p16.3

Target Gene Details

• Entrez Gene ID: 4043
• Gene Name: LDL receptor related protein associated protein 1
• Gene Aliases: A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP
• Location: Chr.4:3503597-3532497 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LRPAP1	NM_002337.3			NP_002328.1
	NR_110005.1
	AK222504.1			BAD96224.1
	AK222527.1			BAD96247.1
	AK292321.1
	AK311600.1
	AK312698.1
	BC105074.1			AAI05075.1
	BC112067.1			AAI12068.1
	BX647984.1
	M63959.1			AAA51553.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv998670	Chr.4:3452060 - 3907808 on Build GRCh38	Gain	LRPAP1 DOK7 LOC100133461 LINC00955 ADRA2C
nsv829841	Chr.4:3500691 - 3661692 on Build GRCh38	Loss	LRPAP1 DOK7 LINC00955
nsv949767	Chr.4:3509374 - 3545773 on Build GRCh38	Deletion	LRPAP1
nsv428435	Chr.4:3385046 - 3621594 on Build GRCh38	Gain	LRPAP1 HGFAC DOK7 LINC00955 RGS12
nsv508992	Chr.4:3455794 - 3533692 on Build GRCh38	Insertion	LRPAP1 DOK7
esv2759219	Chr.4:3392617 - 4349259 on Build GRCh38	Gain	LRPAP1 LYAR HGFAC DOK7 FAM86EP OTOP1 LOC100133461 LINC00955 RGS12 ADRA2C ZBTB49 TMEM128
nsv10426	Chr.4:3477763 - 3565983 on Build GRCh38	Gain+Loss	LRPAP1 DOK7
nsv829840	Chr.4:3442489 - 3621304 on Build GRCh38	Loss	LRPAP1 HGFAC DOK7 LINC00955
nsv470004	Chr.4:3428129 - 3582646 on Build GRCh38	Loss	LRPAP1 HGFAC DOK7 LINC00955 RGS12
nsv593459	Chr.4:3484059 - 3520956 on Build GRCh38	Loss	LRPAP1 DOK7

More Information

Additional Information:

For this assay, SNP(s) [rs73793979] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

chaperone

Gene Ontology Categories:

Process(es)

protein folding
receptor-mediated endocytosis
negative regulation of very-low-density lipoprotein particle clearance
vesicle-mediated transport
negative regulation of protein binding
extracellular negative regulation of signal transduction
negative regulation of beta-amyloid clearance

Function(s)

asialoglycoprotein receptor activity
protein binding
heparin binding
lipase binding
receptor antagonist activity
low-density lipoprotein particle receptor binding
unfolded protein binding
very-low-density lipoprotein particle receptor binding