Hs03700287_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136888664 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MIR4292 PHPT1 MIR4479 C9orf172 EDF1 FBXW5 TRAF2 RABL6 MAMDC4
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	PHPT1 C9orf142 ABCA2 C9orf172 EDF1 TRAF2 MIR6722 LCN15 PRR31 MAMDC4 LCNL1 FBXW5 LCN8 RABL6 C8G LCN10 LOC100128593 PTGDS CLIC3 LCN12 MIR4292 CCDC183 TMEM141 LCN6 MIR4479 CCDC183-AS1
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	LOC101930307 C9orf172 PRR31 FAM166A MAMDC4 STPG3 TUBB4B NSMF LCNL1 FBXW5 DPP7 MIR3621 C8G LRRC26 ANAPC2 ENTPD2 PTGDS TOR4A CLIC3 LCN12 SSNA1 EXD3 TPRN MIR7114 MIR4479 GRIN1 RNF224 C9orf173-AS1 CCDC183-AS1 MAN1B1 PHPT1 C9orf142 ABCA2 EDF1 TRAF2 ENTPD8 SAPCD2 NRARP NOXA1 NDOR1 NPDC1 RABL6 TMEM210 TMEM203 PNPLA7 FUT7 C9orf139 UAP1L1 RNF208 NELFB SLC34A3 MIR4292 CCDC183 CYSRT1 MAN1B1-AS1
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	PHPT1 AGPAT2 C9orf172 EDF1 LINC01451 TRAF2 MIR6722 LCN15 SNORA17A MAMDC4 FAM69B MIR4673 MIR126 SNORA17B NOTCH1 NALT1 SEC16A EGFL7 GPSM1 LCN8 RABL6 LCN10 HSPC324 DNLZ LOC100128593 MIR4674 INPP5E CARD9 SNAPC4 C9orf163 SNHG7 MIR4292 SDCCAG3 CCDC183 PMPCA TMEM141 LCN6 MIR4479 CCDC183-AS1
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	LOC101930307 AGPAT2 C9orf172 LINC01451 MIR6722 LCN15 PRR31 MAMDC4 MIR4673 SNORA17B NOTCH1 LCNL1 NALT1 FBXW5 DPP7 LCN8 MIR3621 C8G LRRC26 LCN10 HSPC324 ENTPD2 PTGDS CLIC3 INPP5E CARD9 LCN12 PMPCA MIR4479 GRIN1 CCDC183-AS1 MAN1B1 PHPT1 C9orf142 ABCA2 EDF1 TRAF2 SNORA17A SAPCD2 FAM69B MIR126 SEC16A EGFL7 NPDC1 RABL6 TMEM210 DNLZ LOC100128593 MIR4674 FUT7 SNAPC4 C9orf139 UAP1L1 C9orf163 SNHG7 MIR4292 SDCCAG3 CCDC183 TMEM141 LCN6 MAN1B1-AS1
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	LOC101930307 AGPAT2 C9orf172 LINC01451 MIR6722 LCN15 PRR31 FAM166A MAMDC4 SNORA17B STPG3 TUBB4B LCNL1 FBXW5 DPP7 LCN8 MIR3621 C8G LRRC26 LCN10 HSPC324 ANAPC2 ENTPD2 PTGDS TOR4A CLIC3 LCN12 SSNA1 EXD3 TPRN MIR4479 GRIN1 RNF224 C9orf173-AS1 CCDC183-AS1 MAN1B1 PHPT1 C9orf142 ABCA2 EDF1 TRAF2 SNORA17A SAPCD2 FAM69B MIR126 NRARP EGFL7 NDOR1 NPDC1 RABL6 TMEM210 LOC100128593 TMEM203 FUT7 C9orf139 UAP1L1 RNF208 NELFB SLC34A3 SNHG7 MIR4292 CCDC183 CYSRT1 TMEM141 LCN6 MAN1B1-AS1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding