Hs03701539_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136887717 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MAMDC4 MIR4479 RABL6 PHPT1 C9orf172 FBXW5 EDF1 TRAF2 MIR4292
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	PTGDS ABCA2 LCN12 TRAF2 MIR4292 LCN15 LCN8 MIR6722 RABL6 LOC100128593 PRR31 CCDC183 C8G CCDC183-AS1 TMEM141 CLIC3 C9orf172 FBXW5 LCN10 MAMDC4 MIR4479 LCN6 C9orf142 PHPT1 EDF1 LCNL1
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	MAN1B1-AS1 MAN1B1 UAP1L1 NSMF PTGDS LCN12 SLC34A3 C9orf173-AS1 GRIN1 RABL6 CYSRT1 SSNA1 ENTPD8 CCDC183-AS1 RNF208 TUBB4B MIR3621 NOXA1 DPP7 MIR4479 TOR4A STPG3 FAM166A EXD3 EDF1 NDOR1 TMEM203 NELFB ABCA2 SAPCD2 PNPLA7 TRAF2 MIR4292 C9orf139 NPDC1 RNF224 PRR31 LRRC26 CCDC183 MIR7114 C8G TMEM210 LOC101930307 NRARP FUT7 CLIC3 C9orf172 FBXW5 MAMDC4 C9orf142 TPRN PHPT1 ANAPC2 LCNL1 ENTPD2
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	LINC01451 SNAPC4 NOTCH1 TRAF2 MIR4292 SNHG7 GPSM1 MIR4674 LCN15 LCN8 MIR6722 RABL6 LOC100128593 CCDC183 C9orf163 CCDC183-AS1 INPP5E SEC16A SDCCAG3 FAM69B TMEM141 SNORA17A NALT1 C9orf172 CARD9 LCN10 MIR4673 PMPCA DNLZ MAMDC4 MIR4479 MIR126 LCN6 EGFL7 PHPT1 SNORA17B HSPC324 EDF1 AGPAT2
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	MAN1B1-AS1 MAN1B1 UAP1L1 PTGDS SNAPC4 LCN12 GRIN1 SNHG7 LCN15 MIR6722 RABL6 LOC100128593 C9orf163 CCDC183-AS1 INPP5E SDCCAG3 NALT1 MIR3621 CARD9 DPP7 MIR4673 DNLZ MIR4479 LCN6 SNORA17B EDF1 AGPAT2 LINC01451 ABCA2 SAPCD2 NOTCH1 TRAF2 MIR4292 MIR4674 LCN8 C9orf139 NPDC1 PRR31 LRRC26 CCDC183 C8G TMEM210 SEC16A LOC101930307 FAM69B TMEM141 FUT7 SNORA17A CLIC3 C9orf172 FBXW5 LCN10 PMPCA MAMDC4 MIR126 C9orf142 EGFL7 PHPT1 HSPC324 LCNL1 ENTPD2
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	MAN1B1-AS1 MAN1B1 UAP1L1 PTGDS LCN12 SLC34A3 C9orf173-AS1 GRIN1 SNHG7 LCN15 MIR6722 RABL6 CYSRT1 LOC100128593 SSNA1 CCDC183-AS1 RNF208 TUBB4B MIR3621 DPP7 MIR4479 TOR4A LCN6 STPG3 FAM166A EXD3 SNORA17B EDF1 AGPAT2 LINC01451 NDOR1 TMEM203 NELFB ABCA2 SAPCD2 TRAF2 MIR4292 LCN8 C9orf139 NPDC1 RNF224 PRR31 LRRC26 CCDC183 C8G TMEM210 LOC101930307 NRARP FAM69B TMEM141 FUT7 SNORA17A CLIC3 C9orf172 FBXW5 LCN10 MAMDC4 MIR126 C9orf142 TPRN EGFL7 PHPT1 ANAPC2 HSPC324 LCNL1 ENTPD2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding