Hs03701539_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136887717 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	PHPT1 C9orf172 FBXW5 MAMDC4 EDF1 MIR4479 TRAF2 MIR4292 RABL6
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	C8G LCN12 MAMDC4 LCNL1 C9orf142 TMEM141 ABCA2 C9orf172 LCN6 CCDC183 MIR4479 CCDC183-AS1 LCN15 LCN8 MIR4292 LOC100128593 PRR31 CLIC3 PHPT1 FBXW5 LCN10 EDF1 PTGDS TRAF2 RABL6 MIR6722
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	EXD3 SAPCD2 C8G UAP1L1 MAN1B1 MAMDC4 C9orf142 LRRC26 RNF208 C9orf172 C9orf173-AS1 CCDC183 TPRN MIR4479 NDOR1 NRARP GRIN1 DPP7 MIR4292 ENTPD2 FAM166A PRR31 CLIC3 NSMF FBXW5 TOR4A EDF1 PTGDS NOXA1 MIR7114 STPG3 PNPLA7 CYSRT1 NPDC1 LCN12 LCNL1 C9orf139 ENTPD8 ABCA2 MAN1B1-AS1 MIR3621 ANAPC2 RNF224 SSNA1 FUT7 TMEM210 CCDC183-AS1 TMEM203 NELFB PHPT1 LOC101930307 TRAF2 SLC34A3 RABL6 TUBB4B
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	SAPCD2 AGPAT2 C8G UAP1L1 MAN1B1 MAMDC4 C9orf142 LRRC26 TMEM141 SNHG7 LINC01451 MIR4673 C9orf172 MIR126 C9orf163 CCDC183 MIR4479 LCN15 LCN8 GRIN1 DPP7 MIR4292 PMPCA ENTPD2 SDCCAG3 PRR31 CLIC3 FBXW5 EDF1 NALT1 PTGDS NOTCH1 DNLZ NPDC1 LCN12 LCNL1 C9orf139 SNAPC4 ABCA2 MAN1B1-AS1 MIR3621 CARD9 LCN6 FUT7 TMEM210 CCDC183-AS1 SNORA17B FAM69B EGFL7 SEC16A SNORA17A LOC100128593 MIR4674 PHPT1 LCN10 LOC101930307 INPP5E HSPC324 TRAF2 RABL6 MIR6722
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	DNLZ AGPAT2 MAMDC4 TMEM141 SNHG7 LINC01451 SNAPC4 MIR4673 CARD9 C9orf172 LCN6 MIR126 C9orf163 CCDC183 MIR4479 CCDC183-AS1 SNORA17B FAM69B LCN15 LCN8 EGFL7 SEC16A SNORA17A MIR4292 LOC100128593 PMPCA SDCCAG3 MIR4674 PHPT1 GPSM1 LCN10 INPP5E EDF1 NALT1 HSPC324 TRAF2 RABL6 MIR6722 NOTCH1
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	EXD3 SAPCD2 AGPAT2 C8G UAP1L1 MAN1B1 MAMDC4 C9orf142 LRRC26 TMEM141 SNHG7 LINC01451 RNF208 C9orf172 C9orf173-AS1 MIR126 CCDC183 TPRN MIR4479 NDOR1 LCN15 LCN8 NRARP GRIN1 DPP7 MIR4292 ENTPD2 FAM166A PRR31 CLIC3 FBXW5 TOR4A EDF1 PTGDS STPG3 CYSRT1 NPDC1 LCN12 LCNL1 C9orf139 ABCA2 MAN1B1-AS1 MIR3621 ANAPC2 LCN6 RNF224 SSNA1 FUT7 TMEM210 CCDC183-AS1 SNORA17B FAM69B TMEM203 NELFB EGFL7 SNORA17A LOC100128593 PHPT1 LCN10 LOC101930307 HSPC324 TRAF2 SLC34A3 RABL6 TUBB4B MIR6722

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding