Hs03701782_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136890882 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MIR4292 C9orf172 MIR4479 RABL6 FBXW5 PHPT1 EDF1 MAMDC4 TRAF2
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LCN10 TMEM141 PTGDS PRR31 FBXW5 LOC100128593 LCN6 CCDC183-AS1 LCN12 C8G CCDC183 MIR4479 PHPT1 ABCA2 MAMDC4 LCN15 MIR4292 RABL6 C9orf142 TRAF2 LCNL1 MIR6722 C9orf172 EDF1 LCN8 CLIC3
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	ENTPD8 TPRN EXD3 PRR31 LOC101930307 CCDC183-AS1 LCN12 C8G MIR7114 MIR4479 PHPT1 ABCA2 MAMDC4 RNF224 LRRC26 NRARP STPG3 ENTPD2 RABL6 C9orf142 C9orf173-AS1 NSMF MAN1B1 SLC34A3 UAP1L1 EDF1 TMEM203 MAN1B1-AS1 NPDC1 MIR3621 SAPCD2 PTGDS FBXW5 TOR4A NOXA1 TMEM210 CCDC183 ANAPC2 FAM166A FUT7 C9orf139 CYSRT1 SSNA1 MIR4292 GRIN1 NDOR1 TRAF2 LCNL1 DPP7 TUBB4B C9orf172 NELFB CLIC3 RNF208 PNPLA7
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	EGFL7 AGPAT2 TMEM141 PRR31 LOC101930307 HSPC324 CCDC183-AS1 LCN12 C8G MIR4479 CARD9 PHPT1 ABCA2 MAMDC4 LRRC26 SDCCAG3 DNLZ ENTPD2 SNORA17B RABL6 C9orf142 SEC16A MAN1B1 UAP1L1 EDF1 FAM69B SNHG7 LCN8 MAN1B1-AS1 NPDC1 NALT1 MIR3621 SAPCD2 C9orf163 LCN10 PTGDS FBXW5 SNORA17A MIR126 LOC100128593 LCN6 TMEM210 CCDC183 NOTCH1 LCN15 PMPCA FUT7 C9orf139 MIR4673 LINC01451 MIR4292 GRIN1 TRAF2 SNAPC4 LCNL1 DPP7 MIR6722 MIR4674 C9orf172 CLIC3 INPP5E
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	EGFL7 C9orf163 LCN10 AGPAT2 TMEM141 SNORA17A MIR126 LOC100128593 HSPC324 LCN6 CCDC183-AS1 CCDC183 MIR4479 CARD9 PHPT1 MAMDC4 NOTCH1 LCN15 PMPCA MIR4673 LINC01451 SDCCAG3 DNLZ MIR4292 SNORA17B RABL6 TRAF2 SNAPC4 SEC16A MIR6722 MIR4674 C9orf172 GPSM1 EDF1 FAM69B SNHG7 LCN8 NALT1 INPP5E
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	EGFL7 AGPAT2 TMEM141 TPRN EXD3 PRR31 LOC101930307 HSPC324 CCDC183-AS1 LCN12 C8G MIR4479 PHPT1 ABCA2 MAMDC4 RNF224 LRRC26 NRARP STPG3 ENTPD2 SNORA17B RABL6 C9orf142 C9orf173-AS1 MAN1B1 SLC34A3 UAP1L1 EDF1 TMEM203 FAM69B SNHG7 LCN8 MAN1B1-AS1 NPDC1 MIR3621 SAPCD2 LCN10 PTGDS FBXW5 SNORA17A MIR126 TOR4A LOC100128593 LCN6 TMEM210 CCDC183 ANAPC2 FAM166A LCN15 FUT7 C9orf139 CYSRT1 SSNA1 LINC01451 MIR4292 GRIN1 NDOR1 TRAF2 LCNL1 DPP7 TUBB4B MIR6722 C9orf172 NELFB CLIC3 RNF208

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding