Hs03701782_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136890882 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	C9orf172 MIR4479 PHPT1 RABL6 MAMDC4 TRAF2 EDF1 MIR4292 FBXW5
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	TMEM141 LCN10 MIR4479 EDF1 C9orf142 MIR4292 FBXW5 PTGDS RABL6 LCNL1 MAMDC4 LCN15 MIR6722 LCN12 TRAF2 C8G PHPT1 CCDC183-AS1 PRR31 C9orf172 LCN8 ABCA2 CCDC183 LCN6 CLIC3 LOC100128593
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	MIR3621 MAN1B1 TOR4A MAN1B1-AS1 NELFB EDF1 NDOR1 ANAPC2 PNPLA7 LCNL1 EXD3 CYSRT1 LCN12 DPP7 RNF224 C9orf139 SSNA1 C8G CCDC183-AS1 SAPCD2 C9orf173-AS1 LOC101930307 NPDC1 TMEM203 CCDC183 CLIC3 TUBB4B STPG3 MIR4479 GRIN1 FUT7 RNF208 MIR7114 C9orf142 UAP1L1 MIR4292 FBXW5 NRARP PTGDS RABL6 MAMDC4 ENTPD8 TRAF2 SLC34A3 PHPT1 TMEM210 PRR31 LRRC26 NOXA1 C9orf172 ABCA2 TPRN ENTPD2 NSMF FAM166A
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	TMEM141 GPSM1 LCN10 NALT1 MIR4479 SNORA17A SNAPC4 C9orf163 EDF1 MIR4292 PMPCA CARD9 SEC16A RABL6 MAMDC4 LCN15 MIR6722 SDCCAG3 MIR4673 TRAF2 EGFL7 PHPT1 SNORA17B NOTCH1 FAM69B CCDC183-AS1 INPP5E C9orf172 SNHG7 LCN8 MIR4674 HSPC324 DNLZ MIR126 CCDC183 LCN6 LINC01451 LOC100128593 AGPAT2
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	MIR3621 MAN1B1 MAN1B1-AS1 SNORA17A C9orf163 EDF1 PMPCA CARD9 LCNL1 LCN15 LCN12 MIR4673 DPP7 C9orf139 EGFL7 C8G SNORA17B NOTCH1 FAM69B CCDC183-AS1 SAPCD2 LOC101930307 LCN8 NPDC1 CCDC183 LCN6 CLIC3 LINC01451 LOC100128593 TMEM141 LCN10 NALT1 MIR4479 GRIN1 FUT7 SNAPC4 C9orf142 UAP1L1 MIR4292 FBXW5 PTGDS SEC16A RABL6 MAMDC4 MIR6722 SDCCAG3 TRAF2 PHPT1 TMEM210 PRR31 LRRC26 INPP5E C9orf172 SNHG7 MIR4674 ABCA2 HSPC324 DNLZ ENTPD2 MIR126 AGPAT2
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	MIR3621 MAN1B1 TOR4A MAN1B1-AS1 NELFB SNORA17A EDF1 NDOR1 ANAPC2 LCNL1 EXD3 LCN15 CYSRT1 LCN12 DPP7 RNF224 C9orf139 EGFL7 SSNA1 C8G SNORA17B FAM69B CCDC183-AS1 SAPCD2 C9orf173-AS1 LOC101930307 LCN8 NPDC1 TMEM203 CCDC183 LCN6 CLIC3 LINC01451 LOC100128593 TMEM141 LCN10 TUBB4B STPG3 MIR4479 GRIN1 FUT7 RNF208 C9orf142 UAP1L1 MIR4292 FBXW5 NRARP PTGDS RABL6 MAMDC4 MIR6722 TRAF2 SLC34A3 PHPT1 TMEM210 PRR31 LRRC26 C9orf172 SNHG7 ABCA2 HSPC324 TPRN ENTPD2 MIR126 FAM166A AGPAT2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding