Hs03708775_cn

• Gene Symbol: ANAPC2
• Assay Reference Genome Location: Chr.9:137179415 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 29882
• Gene Name: anaphase promoting complex subunit 2
• Gene Aliases: APC2
• Location: Chr.9:137174784-137188605 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ANAPC2	NM_013366.3			NP_037498.1
	AB037827.1			BAA92644.1
	AF191337.1			AAF05751.1
	AK294601.1
	BC001579.1			AAH01579.1
	BC009487.2			AAH09487.2
	BC032503.1			AAH32503.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv616007	Chr.9:137079368 - 137240666 on Build GRCh38	Loss	TPRN SSNA1 LOC101930307 MIR3621 MAN1B1-AS1 RNF224 UAP1L1 TMEM210 NDOR1 TMEM203 SLC34A3 DPP7 LRRC26 ANAPC2 GRIN1 RNF208 MAN1B1 CYSRT1
dgv13009n54	Chr.9:137173890 - 137327859 on Build GRCh38	Loss	TPRN NRARP SSNA1 RNF224 C9orf173-AS1 FAM166A STPG3 NDOR1 TMEM203 SLC34A3 ANAPC2 NELFB RNF208 CYSRT1 EXD3 TUBB4B TOR4A
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	LCN12 NRARP CCDC183 SSNA1 MAN1B1-AS1 RNF224 C9orf173-AS1 EDF1 NDOR1 SAPCD2 MIR4479 CLIC3 CYSRT1 TOR4A CCDC183-AS1 PHPT1 FAM166A C9orf139 NOXA1 MIR4292 C9orf172 ABCA2 SLC34A3 DPP7 NELFB TRAF2 GRIN1 C9orf142 EXD3 TUBB4B PRR31 FUT7 LOC101930307 RABL6 PNPLA7 MIR7114 TMEM203 MAMDC4 LRRC26 NSMF C8G RNF208 ENTPD8 NPDC1 TPRN MIR3621 UAP1L1 TMEM210 STPG3 LCNL1 ANAPC2 MAN1B1 PTGDS FBXW5 ENTPD2
nsv951207	Chr.9:137136949 - 137379148 on Build GRCh38	Deletion	TPRN NRARP SSNA1 MIR3621 RNF224 C9orf173-AS1 FAM166A TMEM210 STPG3 NDOR1 TMEM203 SLC34A3 LRRC26 ANAPC2 NELFB GRIN1 RNF208 CYSRT1 EXD3 TUBB4B TOR4A
nsv1161918	Chr.9:137118319 - 137438026 on Build GRCh38	Duplication	TPRN NRARP SSNA1 MIR3621 RNF224 C9orf173-AS1 FAM166A NOXA1 TMEM210 STPG3 NDOR1 TMEM203 SLC34A3 LRRC26 ANAPC2 NELFB GRIN1 RNF208 ENTPD8 CYSRT1 EXD3 TUBB4B TOR4A
esv2761561	Chr.9:137030185 - 137191593 on Build GRCh38	Gain	NPDC1 FUT7 SSNA1 LOC101930307 MIR3621 MAN1B1-AS1 UAP1L1 C9orf139 TMEM210 DPP7 SAPCD2 LRRC26 ANAPC2 GRIN1 MAN1B1 ENTPD2
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	LCN12 NRARP CCDC183 SSNA1 MAN1B1-AS1 RNF224 SNHG7 C9orf173-AS1 EDF1 NDOR1 SAPCD2 LCN10 MIR4479 CLIC3 CYSRT1 TOR4A CCDC183-AS1 LOC100128593 LCN6 EGFL7 PHPT1 FAM166A C9orf139 LINC01451 MIR4292 C9orf172 ABCA2 SLC34A3 DPP7 NELFB TRAF2 GRIN1 MIR126 C9orf142 EXD3 TUBB4B LCN15 PRR31 SNORA17B FUT7 LOC101930307 SNORA17A RABL6 TMEM203 MAMDC4 LRRC26 C8G RNF208 AGPAT2 NPDC1 TPRN HSPC324 MIR3621 FAM69B TMEM141 MIR6722 UAP1L1 TMEM210 STPG3 LCNL1 ANAPC2 MAN1B1 PTGDS FBXW5 ENTPD2 LCN8

More Information

Additional Information:

For this assay, SNP(s) [rs73571567] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitotic nuclear division
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of axon extension
positive regulation of dendrite morphogenesis
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K11-linked ubiquitination
positive regulation of synapse maturation

Function(s)

ubiquitin protein ligase binding
ubiquitin protein ligase activity