Hs03708775_cn

• Gene Symbol: ANAPC2
• Assay Reference Genome Location: Chr.9:137179415 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 29882
• Gene Name: anaphase promoting complex subunit 2
• Gene Aliases: APC2
• Location: Chr.9:137174784-137188605 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ANAPC2	NM_013366.3			NP_037498.1
	AB037827.1			BAA92644.1
	AF191337.1			AAF05751.1
	AK294601.1
	BC001579.1			AAH01579.1
	BC009487.2			AAH09487.2
	BC032503.1			AAH32503.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv616007	Chr.9:137079368 - 137240666 on Build GRCh38	Loss	SSNA1 SLC34A3 NDOR1 TPRN UAP1L1 MAN1B1-AS1 DPP7 RNF208 TMEM210 LRRC26 ANAPC2 MIR3621 CYSRT1 RNF224 LOC101930307 MAN1B1 TMEM203 GRIN1
dgv13009n54	Chr.9:137173890 - 137327859 on Build GRCh38	Loss	NELFB SSNA1 SLC34A3 C9orf173-AS1 NDOR1 TPRN NRARP TUBB4B RNF208 EXD3 STPG3 ANAPC2 FAM166A CYSRT1 RNF224 TMEM203 TOR4A
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	C9orf142 SAPCD2 NRARP MAN1B1-AS1 TMEM210 C9orf139 STPG3 CCDC183-AS1 FAM166A PTGDS PHPT1 NPDC1 TOR4A MIR4479 FUT7 TPRN UAP1L1 RNF208 EXD3 LRRC26 MIR3621 PNPLA7 MAN1B1 LCNL1 GRIN1 SSNA1 C9orf173-AS1 RABL6 ENTPD8 MIR7114 TUBB4B ABCA2 MIR4292 NOXA1 C8G ENTPD2 TMEM203 MAMDC4 CLIC3 NELFB SLC34A3 NDOR1 PRR31 C9orf172 CCDC183 TRAF2 DPP7 EDF1 ANAPC2 FBXW5 LCN12 CYSRT1 RNF224 LOC101930307 NSMF
nsv951207	Chr.9:137136949 - 137379148 on Build GRCh38	Deletion	NELFB SSNA1 SLC34A3 C9orf173-AS1 NDOR1 TPRN NRARP TUBB4B RNF208 TMEM210 EXD3 LRRC26 STPG3 ANAPC2 FAM166A MIR3621 CYSRT1 RNF224 TMEM203 GRIN1 TOR4A
esv2761561	Chr.9:137030185 - 137191593 on Build GRCh38	Gain	SSNA1 FUT7 SAPCD2 UAP1L1 MAN1B1-AS1 DPP7 TMEM210 LRRC26 C9orf139 ANAPC2 MIR3621 NPDC1 LOC101930307 ENTPD2 MAN1B1 GRIN1
nsv1161918	Chr.9:137118319 - 137438026 on Build GRCh38	Duplication	NELFB SSNA1 SLC34A3 C9orf173-AS1 NDOR1 ENTPD8 TPRN NRARP TUBB4B RNF208 TMEM210 EXD3 LRRC26 STPG3 ANAPC2 FAM166A MIR3621 NOXA1 CYSRT1 RNF224 TMEM203 GRIN1 TOR4A
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	C9orf142 FAM69B SAPCD2 NRARP MAN1B1-AS1 SNHG7 MIR126 TMEM210 C9orf139 STPG3 CCDC183-AS1 FAM166A SNORA17B PTGDS PHPT1 NPDC1 TOR4A TMEM141 MIR4479 LCN8 FUT7 TPRN UAP1L1 RNF208 EXD3 LRRC26 EGFL7 MIR3621 LCN10 MAN1B1 LCNL1 GRIN1 SSNA1 C9orf173-AS1 RABL6 TUBB4B MIR6722 ABCA2 LCN15 SNORA17A HSPC324 MIR4292 AGPAT2 C8G ENTPD2 TMEM203 MAMDC4 LCN6 CLIC3 NELFB SLC34A3 NDOR1 PRR31 C9orf172 CCDC183 TRAF2 DPP7 EDF1 ANAPC2 FBXW5 LCN12 LINC01451 CYSRT1 LOC100128593 RNF224 LOC101930307

More Information

Additional Information:

For this assay, SNP(s) [rs73571567] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitotic nuclear division
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of axon extension
positive regulation of dendrite morphogenesis
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K11-linked ubiquitination
positive regulation of synapse maturation

Function(s)

ubiquitin protein ligase binding
ubiquitin protein ligase activity