Hs03710641_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136890486 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2	1	878	XP_011517276.1
	XM_011518975.2	2	205	XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 RABL6 EDF1 C9orf172 MIR4292 MIR4479 PHPT1 MAMDC4 FBXW5
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	CLIC3 RABL6 EDF1 C9orf172 ABCA2 MIR6722 TMEM141 LOC100128593 C8G LCN15 MAMDC4 LCNL1 CCDC183 MIR4292 LCN10 MIR4479 PRR31 CCDC183-AS1 FBXW5 LCN12 TRAF2 C9orf142 PHPT1 PTGDS LCN8 LCN6
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	CLIC3 NSMF RABL6 C9orf172 MIR3621 LOC101930307 MIR7114 TPRN NOXA1 NPDC1 GRIN1 C8G MAMDC4 RNF224 SAPCD2 CCDC183 MAN1B1 MIR4479 PRR31 CCDC183-AS1 FBXW5 NRARP TMEM203 PHPT1 TUBB4B PTGDS NELFB EDF1 EXD3 ABCA2 RNF208 TMEM210 UAP1L1 C9orf139 C9orf173-AS1 NDOR1 LCNL1 LRRC26 SSNA1 FUT7 MIR4292 DPP7 SLC34A3 TOR4A LCN12 MAN1B1-AS1 FAM166A TRAF2 ENTPD2 C9orf142 ENTPD8 PNPLA7 ANAPC2 STPG3 CYSRT1
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	SNAPC4 RABL6 EDF1 C9orf172 EGFL7 HSPC324 DNLZ SNHG7 MIR6722 GPSM1 INPP5E TMEM141 LOC100128593 LCN15 MAMDC4 NALT1 SEC16A SNORA17A LINC01451 MIR4673 CCDC183 SDCCAG3 CARD9 MIR4292 LCN10 MIR4479 SNORA17B CCDC183-AS1 FAM69B MIR4674 NOTCH1 TRAF2 MIR126 PMPCA C9orf163 PHPT1 AGPAT2 LCN8 LCN6
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	SNAPC4 CLIC3 RABL6 C9orf172 MIR3621 LOC101930307 HSPC324 NPDC1 GRIN1 TMEM141 LOC100128593 C8G MAMDC4 SEC16A SAPCD2 MIR4673 CCDC183 SDCCAG3 MAN1B1 LCN10 MIR4479 PRR31 SNORA17B CCDC183-AS1 FBXW5 MIR4674 PMPCA PHPT1 PTGDS EDF1 ABCA2 EGFL7 DNLZ TMEM210 SNHG7 UAP1L1 MIR6722 INPP5E C9orf139 LCN15 NALT1 LCNL1 SNORA17A LRRC26 LINC01451 CARD9 FUT7 MIR4292 DPP7 LCN12 FAM69B MAN1B1-AS1 NOTCH1 TRAF2 ENTPD2 MIR126 C9orf142 C9orf163 AGPAT2 LCN8 LCN6
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	CLIC3 RABL6 C9orf172 MIR3621 LOC101930307 HSPC324 TPRN NPDC1 GRIN1 TMEM141 LOC100128593 C8G MAMDC4 RNF224 SAPCD2 CCDC183 MAN1B1 LCN10 MIR4479 PRR31 SNORA17B CCDC183-AS1 FBXW5 NRARP TMEM203 PHPT1 TUBB4B PTGDS NELFB EDF1 EXD3 ABCA2 EGFL7 RNF208 TMEM210 SNHG7 UAP1L1 MIR6722 C9orf139 C9orf173-AS1 LCN15 NDOR1 LCNL1 SNORA17A LRRC26 LINC01451 SSNA1 FUT7 MIR4292 DPP7 SLC34A3 TOR4A LCN12 FAM69B MAN1B1-AS1 FAM166A TRAF2 ENTPD2 MIR126 C9orf142 AGPAT2 ANAPC2 STPG3 CYSRT1 LCN8 LCN6

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding