Hs03710641_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136890486 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Exon 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2	1	878	XP_011517276.1
	XM_011518975.2	2	205	XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	PHPT1 FBXW5 EDF1 C9orf172 MAMDC4 TRAF2 MIR4292 RABL6 MIR4479
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	PRR31 PHPT1 C9orf172 MIR6722 CCDC183 MIR4292 TMEM141 LOC100128593 LCN8 LCN15 C9orf142 MAMDC4 RABL6 MIR4479 C8G LCNL1 LCN6 FBXW5 EDF1 LCN10 TRAF2 CLIC3 ABCA2 CCDC183-AS1 PTGDS LCN12
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	PRR31 CYSRT1 PNPLA7 C9orf172 NOXA1 MIR4292 NRARP C9orf142 MAMDC4 FUT7 SLC34A3 MIR4479 GRIN1 NSMF SSNA1 TPRN EDF1 MIR3621 NELFB TUBB4B ENTPD8 CLIC3 ABCA2 RNF208 C9orf139 C9orf173-AS1 CCDC183-AS1 NDOR1 PTGDS NPDC1 MAN1B1 PHPT1 STPG3 FAM166A UAP1L1 TOR4A CCDC183 MIR7114 RABL6 ANAPC2 C8G RNF224 LCNL1 TMEM210 FBXW5 DPP7 LOC101930307 TRAF2 EXD3 TMEM203 LRRC26 SAPCD2 ENTPD2 LCN12 MAN1B1-AS1
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	PRR31 NALT1 AGPAT2 PMPCA C9orf172 MIR6722 MIR4292 TMEM141 C9orf142 SNHG7 FAM69B MAMDC4 FUT7 MIR4479 C9orf163 GRIN1 EGFL7 EDF1 MIR3621 LCN10 CLIC3 ABCA2 SEC16A C9orf139 CCDC183-AS1 INPP5E PTGDS NPDC1 MAN1B1 PHPT1 SNAPC4 UAP1L1 CCDC183 DNLZ SNORA17B LOC100128593 LINC01451 LCN8 LCN15 RABL6 C8G LCNL1 TMEM210 LCN6 FBXW5 CARD9 DPP7 SNORA17A LOC101930307 HSPC324 TRAF2 NOTCH1 MIR126 SDCCAG3 LRRC26 MIR4674 SAPCD2 ENTPD2 MIR4673 LCN12 MAN1B1-AS1
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	NALT1 AGPAT2 PHPT1 PMPCA C9orf172 SNAPC4 MIR6722 CCDC183 MIR4292 TMEM141 DNLZ SNORA17B LOC100128593 LINC01451 LCN8 LCN15 SNHG7 FAM69B MAMDC4 RABL6 MIR4479 C9orf163 LCN6 EGFL7 EDF1 CARD9 SNORA17A LCN10 HSPC324 TRAF2 GPSM1 SEC16A NOTCH1 MIR126 CCDC183-AS1 INPP5E SDCCAG3 MIR4674 MIR4673
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	PRR31 AGPAT2 CYSRT1 C9orf172 MIR6722 MIR4292 TMEM141 NRARP C9orf142 SNHG7 FAM69B MAMDC4 FUT7 SLC34A3 MIR4479 GRIN1 SSNA1 EGFL7 TPRN EDF1 MIR3621 NELFB TUBB4B LCN10 CLIC3 ABCA2 RNF208 C9orf139 C9orf173-AS1 CCDC183-AS1 NDOR1 PTGDS NPDC1 MAN1B1 PHPT1 STPG3 FAM166A UAP1L1 TOR4A CCDC183 SNORA17B LOC100128593 LINC01451 LCN8 LCN15 RABL6 ANAPC2 C8G RNF224 LCNL1 TMEM210 LCN6 FBXW5 DPP7 SNORA17A LOC101930307 HSPC324 TRAF2 EXD3 MIR126 TMEM203 LRRC26 SAPCD2 ENTPD2 LCN12 MAN1B1-AS1

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding