Hs03717613_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136888240 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MAMDC4 MIR4479 MIR4292 RABL6 EDF1 C9orf172 TRAF2 FBXW5 PHPT1
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	ABCA2 MIR4479 EDF1 PTGDS TRAF2 FBXW5 LCNL1 CCDC183 MIR6722 CCDC183-AS1 LCN6 PHPT1 LCN12 CLIC3 RABL6 C9orf172 TMEM141 PRR31 LCN10 C9orf142 LOC100128593 MAMDC4 MIR4292 LCN8 LCN15 C8G
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	RNF208 TPRN FBXW5 C9orf173-AS1 TUBB4B STPG3 LCNL1 CCDC183 MAN1B1 PHPT1 LCN12 NELFB SSNA1 MAN1B1-AS1 TMEM210 PRR31 C9orf142 MIR4292 EXD3 ENTPD2 CYSRT1 SAPCD2 PNPLA7 ABCA2 MIR4479 NDOR1 EDF1 ENTPD8 DPP7 PTGDS TRAF2 NOXA1 TMEM203 GRIN1 RNF224 TOR4A MIR7114 CCDC183-AS1 SLC34A3 FUT7 C9orf139 CLIC3 NPDC1 NSMF LOC101930307 RABL6 MIR3621 C9orf172 ANAPC2 NRARP FAM166A MAMDC4 UAP1L1 LRRC26 C8G
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	MIR4674 DNLZ SNHG7 FBXW5 AGPAT2 MIR126 LCNL1 LINC01451 CCDC183 MAN1B1 PHPT1 LCN12 C9orf163 FAM69B MAN1B1-AS1 TMEM210 TMEM141 PRR31 LCN10 CARD9 C9orf142 SEC16A LOC100128593 SNAPC4 MIR4292 NOTCH1 ENTPD2 SAPCD2 LCN15 ABCA2 MIR4479 EDF1 DPP7 PTGDS TRAF2 GRIN1 HSPC324 MIR6722 CCDC183-AS1 FUT7 LCN6 C9orf139 CLIC3 NPDC1 MIR4673 SNORA17B LOC101930307 RABL6 SDCCAG3 MIR3621 C9orf172 NALT1 SNORA17A PMPCA MAMDC4 UAP1L1 INPP5E LCN8 LRRC26 EGFL7 C8G
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	MIR4674 MIR4479 DNLZ EDF1 SNHG7 TRAF2 AGPAT2 MIR126 LINC01451 HSPC324 CCDC183 MIR6722 CCDC183-AS1 LCN6 PHPT1 C9orf163 MIR4673 SNORA17B FAM69B RABL6 GPSM1 SDCCAG3 C9orf172 TMEM141 LCN10 CARD9 SEC16A NALT1 SNORA17A PMPCA LOC100128593 MAMDC4 INPP5E SNAPC4 MIR4292 LCN8 NOTCH1 LCN15 EGFL7
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	RNF208 TPRN SNHG7 FBXW5 C9orf173-AS1 AGPAT2 MIR126 TUBB4B STPG3 LCNL1 LINC01451 CCDC183 MAN1B1 PHPT1 LCN12 NELFB SSNA1 FAM69B MAN1B1-AS1 TMEM210 TMEM141 PRR31 LCN10 C9orf142 LOC100128593 MIR4292 EXD3 ENTPD2 CYSRT1 SAPCD2 LCN15 ABCA2 MIR4479 NDOR1 EDF1 DPP7 PTGDS TRAF2 TMEM203 GRIN1 RNF224 TOR4A HSPC324 MIR6722 CCDC183-AS1 SLC34A3 FUT7 LCN6 C9orf139 CLIC3 NPDC1 SNORA17B LOC101930307 RABL6 MIR3621 C9orf172 ANAPC2 NRARP SNORA17A FAM166A MAMDC4 UAP1L1 LCN8 LRRC26 EGFL7 C8G

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding