Hs03717613_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136888240 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MAMDC4 MIR4479 PHPT1 MIR4292 C9orf172 EDF1 TRAF2 RABL6 FBXW5
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	ABCA2 PTGDS LCN12 TRAF2 FBXW5 CCDC183-AS1 C9orf142 MAMDC4 TMEM141 LCN8 LCN15 RABL6 LOC100128593 MIR6722 MIR4479 PHPT1 CCDC183 PRR31 MIR4292 LCN10 C8G C9orf172 LCN6 EDF1 CLIC3 LCNL1
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	ABCA2 PTGDS LCN12 ENTPD8 LRRC26 TRAF2 ANAPC2 CCDC183-AS1 C9orf142 MAN1B1-AS1 TOR4A NPDC1 EXD3 UAP1L1 SLC34A3 LOC101930307 MIR4479 NOXA1 NELFB PHPT1 C9orf139 CCDC183 RNF224 NRARP MIR4292 TPRN TMEM210 C9orf173-AS1 GRIN1 C8G RNF208 CYSRT1 STPG3 SSNA1 LCNL1 FBXW5 NSMF DPP7 MIR7114 MAMDC4 SAPCD2 TUBB4B RABL6 MAN1B1 PNPLA7 PRR31 FUT7 NDOR1 FAM166A MIR3621 C9orf172 EDF1 CLIC3 ENTPD2 TMEM203
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	FAM69B DNLZ HSPC324 NOTCH1 EGFL7 TRAF2 NALT1 C9orf163 PMPCA CCDC183-AS1 SEC16A MAMDC4 TMEM141 SNORA17B LCN8 MIR4674 LCN15 SNHG7 RABL6 LOC100128593 MIR126 MIR6722 MIR4479 PHPT1 CCDC183 GPSM1 MIR4292 SNAPC4 CARD9 AGPAT2 LCN10 MIR4673 INPP5E LINC01451 SDCCAG3 C9orf172 LCN6 EDF1 SNORA17A
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	ABCA2 PTGDS LCN12 LRRC26 DNLZ HSPC324 NOTCH1 TRAF2 PMPCA CCDC183-AS1 SEC16A C9orf142 MAN1B1-AS1 MIR4674 LCN15 SNHG7 NPDC1 LOC100128593 MIR126 MIR6722 UAP1L1 LOC101930307 MIR4479 PHPT1 C9orf139 CCDC183 MIR4292 SNAPC4 CARD9 AGPAT2 MIR4673 TMEM210 INPP5E GRIN1 C8G SDCCAG3 LCN6 LCNL1 SNORA17A FAM69B EGFL7 FBXW5 NALT1 DPP7 C9orf163 MAMDC4 SAPCD2 TMEM141 SNORA17B LCN8 RABL6 MAN1B1 PRR31 FUT7 LCN10 LINC01451 MIR3621 C9orf172 EDF1 CLIC3 ENTPD2
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	ABCA2 PTGDS LCN12 LRRC26 HSPC324 TRAF2 ANAPC2 CCDC183-AS1 C9orf142 MAN1B1-AS1 TOR4A LCN15 SNHG7 NPDC1 LOC100128593 MIR126 MIR6722 EXD3 UAP1L1 SLC34A3 LOC101930307 MIR4479 NELFB PHPT1 C9orf139 CCDC183 RNF224 NRARP MIR4292 AGPAT2 TPRN TMEM210 C9orf173-AS1 GRIN1 C8G RNF208 CYSRT1 LCN6 STPG3 SSNA1 LCNL1 SNORA17A FAM69B EGFL7 FBXW5 DPP7 MAMDC4 SAPCD2 TMEM141 SNORA17B LCN8 TUBB4B RABL6 MAN1B1 PRR31 FUT7 LCN10 NDOR1 FAM166A LINC01451 MIR3621 C9orf172 EDF1 CLIC3 ENTPD2 TMEM203

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding