Hs03721636_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136883390 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	C9orf172 MIR4292 FBXW5 MIR4479 EDF1 PHPT1 TRAF2 MAMDC4 RABL6
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	FBXW5 LOC100128593 ABCA2 EDF1 MAMDC4 C8G LCN10 CCDC183 C9orf172 MIR4479 PRR31 C9orf142 LCN15 TRAF2 LCN8 CLIC3 CCDC183-AS1 MIR4292 MIR6722 PHPT1 PTGDS LCN6 RABL6 LCN12 LCNL1 TMEM141
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	CYSRT1 ABCA2 EDF1 TOR4A C9orf173-AS1 TMEM210 NPDC1 ENTPD8 NDOR1 C9orf172 LOC101930307 MAN1B1 TRAF2 TPRN NSMF NOXA1 CCDC183-AS1 MIR4292 FUT7 PTGDS UAP1L1 RABL6 C9orf139 LCN12 ENTPD2 EXD3 MIR3621 FBXW5 GRIN1 NRARP MAMDC4 C8G MAN1B1-AS1 CCDC183 FAM166A MIR4479 PRR31 C9orf142 SSNA1 PNPLA7 LRRC26 MIR7114 CLIC3 SAPCD2 PHPT1 ANAPC2 TUBB4B RNF224 DPP7 RNF208 NELFB SLC34A3 LCNL1 STPG3 TMEM203
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	EGFL7 LOC100128593 SNAPC4 EDF1 SNHG7 SDCCAG3 MAMDC4 LCN10 C9orf163 MIR4673 CCDC183 GPSM1 C9orf172 MIR4479 SNORA17B LCN15 NOTCH1 TRAF2 LCN8 AGPAT2 HSPC324 PMPCA CCDC183-AS1 SNORA17A MIR4292 MIR6722 MIR4674 PHPT1 LCN6 SEC16A CARD9 RABL6 INPP5E DNLZ FAM69B NALT1 LINC01451 TMEM141 MIR126
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	LOC100128593 ABCA2 EDF1 TMEM210 SDCCAG3 NPDC1 C9orf163 C9orf172 LOC101930307 MAN1B1 TRAF2 PMPCA CCDC183-AS1 SNORA17A MIR4292 FUT7 PTGDS LCN6 CARD9 UAP1L1 RABL6 DNLZ C9orf139 LCN12 LINC01451 ENTPD2 MIR3621 EGFL7 FBXW5 SNAPC4 GRIN1 SNHG7 MAMDC4 C8G LCN10 MAN1B1-AS1 MIR4673 CCDC183 MIR4479 PRR31 SNORA17B C9orf142 LCN15 LRRC26 NOTCH1 LCN8 AGPAT2 CLIC3 HSPC324 SAPCD2 MIR6722 MIR4674 PHPT1 SEC16A DPP7 INPP5E LCNL1 FAM69B NALT1 TMEM141 MIR126
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	CYSRT1 LOC100128593 ABCA2 EDF1 TOR4A C9orf173-AS1 TMEM210 NPDC1 NDOR1 C9orf172 LOC101930307 MAN1B1 TRAF2 TPRN CCDC183-AS1 SNORA17A MIR4292 FUT7 PTGDS LCN6 UAP1L1 RABL6 C9orf139 LCN12 LINC01451 ENTPD2 EXD3 MIR3621 EGFL7 FBXW5 GRIN1 SNHG7 NRARP MAMDC4 C8G LCN10 MAN1B1-AS1 CCDC183 FAM166A MIR4479 PRR31 SNORA17B C9orf142 SSNA1 LCN15 LRRC26 LCN8 AGPAT2 CLIC3 HSPC324 SAPCD2 MIR6722 PHPT1 ANAPC2 TUBB4B RNF224 DPP7 RNF208 NELFB SLC34A3 LCNL1 FAM69B TMEM141 MIR126 STPG3 TMEM203

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding