Hs03721636_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136883390 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	RABL6 MIR4479 C9orf172 PHPT1 MAMDC4 FBXW5 EDF1 TRAF2 MIR4292
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	TMEM141 RABL6 MIR4479 PHPT1 LCN6 TRAF2 LOC100128593 ABCA2 PTGDS CCDC183-AS1 LCN15 PRR31 C8G MIR4292 LCN8 C9orf142 CLIC3 FBXW5 EDF1 CCDC183 LCNL1 MIR6722 C9orf172 LCN12 MAMDC4 LCN10
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	CYSRT1 NELFB GRIN1 SSNA1 SLC34A3 PHPT1 TRAF2 ABCA2 PTGDS TOR4A PRR31 EXD3 ENTPD8 LOC101930307 DPP7 MIR4292 TUBB4B MAN1B1-AS1 CLIC3 NOXA1 SAPCD2 C9orf139 ENTPD2 EDF1 NRARP CCDC183 PNPLA7 LCNL1 MIR7114 MIR3621 LCN12 MAMDC4 RABL6 C9orf173-AS1 UAP1L1 MIR4479 RNF224 TMEM203 NSMF CCDC183-AS1 NPDC1 TPRN C8G STPG3 C9orf142 NDOR1 LRRC26 FAM166A FBXW5 TMEM210 MAN1B1 FUT7 ANAPC2 RNF208 C9orf172
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	DNLZ GRIN1 NALT1 MIR4673 PHPT1 LCN6 TRAF2 LOC100128593 ABCA2 PTGDS MIR4674 LCN15 INPP5E SNHG7 PRR31 SDCCAG3 LOC101930307 SNORA17B DPP7 MIR4292 MAN1B1-AS1 MIR126 PMPCA CLIC3 LINC01451 SAPCD2 C9orf139 ENTPD2 EDF1 CCDC183 LCNL1 EGFL7 MIR3621 LCN12 MAMDC4 LCN10 TMEM141 RABL6 UAP1L1 MIR4479 SNAPC4 CCDC183-AS1 NPDC1 FAM69B C8G CARD9 LCN8 AGPAT2 C9orf142 LRRC26 FBXW5 SEC16A TMEM210 NOTCH1 MAN1B1 HSPC324 SNORA17A FUT7 MIR6722 C9orf163 C9orf172
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	DNLZ TMEM141 RABL6 NALT1 MIR4673 MIR4479 SNAPC4 PHPT1 LCN6 TRAF2 LOC100128593 MIR4674 CCDC183-AS1 LCN15 INPP5E SNHG7 FAM69B SDCCAG3 SNORA17B MIR4292 CARD9 LCN8 AGPAT2 MIR126 PMPCA LINC01451 EDF1 SEC16A CCDC183 NOTCH1 EGFL7 HSPC324 SNORA17A MIR6722 GPSM1 C9orf163 C9orf172 MAMDC4 LCN10
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	CYSRT1 NELFB GRIN1 SSNA1 SLC34A3 PHPT1 LCN6 TRAF2 LOC100128593 ABCA2 PTGDS LCN15 SNHG7 TOR4A PRR31 EXD3 LOC101930307 SNORA17B DPP7 MIR4292 TUBB4B MAN1B1-AS1 MIR126 CLIC3 LINC01451 SAPCD2 C9orf139 ENTPD2 EDF1 NRARP CCDC183 LCNL1 EGFL7 MIR3621 LCN12 MAMDC4 LCN10 TMEM141 RABL6 C9orf173-AS1 UAP1L1 MIR4479 RNF224 TMEM203 CCDC183-AS1 NPDC1 FAM69B TPRN C8G LCN8 AGPAT2 STPG3 C9orf142 NDOR1 LRRC26 FAM166A FBXW5 TMEM210 MAN1B1 HSPC324 SNORA17A FUT7 ANAPC2 MIR6722 RNF208 C9orf172

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding