Hs03723042_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136886288 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	PHPT1 MIR4479 FBXW5 TRAF2 C9orf172 RABL6 EDF1 MAMDC4 MIR4292
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	PHPT1 LCN8 C9orf172 C8G ABCA2 LCN15 LCN10 MIR6722 CCDC183 RABL6 TMEM141 PTGDS MIR4479 LCN6 C9orf142 FBXW5 TRAF2 PRR31 LCNL1 CLIC3 LOC100128593 CCDC183-AS1 LCN12 EDF1 MAMDC4 MIR4292
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	SAPCD2 FAM166A PHPT1 ENTPD8 ENTPD2 MIR7114 ABCA2 NSMF EXD3 NELFB NOXA1 TUBB4B UAP1L1 DPP7 PTGDS MIR4479 TRAF2 PNPLA7 LCNL1 TPRN ANAPC2 TMEM210 TOR4A RNF208 FUT7 CCDC183-AS1 LCN12 EDF1 MAMDC4 TMEM203 RNF224 SSNA1 C9orf172 LRRC26 C8G MAN1B1-AS1 GRIN1 CYSRT1 CCDC183 RABL6 MIR3621 SLC34A3 LOC101930307 C9orf139 STPG3 C9orf142 FBXW5 PRR31 CLIC3 NRARP NDOR1 C9orf173-AS1 NPDC1 MAN1B1 MIR4292
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	SAPCD2 PHPT1 LCN8 ENTPD2 MIR4674 ABCA2 LCN15 PMPCA LCN10 NALT1 SEC16A UAP1L1 MIR126 DPP7 SNORA17B PTGDS SNHG7 MIR4479 SNORA17A LCN6 TRAF2 LCNL1 TMEM210 AGPAT2 EGFL7 NOTCH1 HSPC324 FUT7 CCDC183-AS1 LCN12 DNLZ MIR4673 LINC01451 EDF1 MAMDC4 C9orf172 LRRC26 C9orf163 C8G INPP5E MAN1B1-AS1 GRIN1 MIR6722 CCDC183 RABL6 SDCCAG3 TMEM141 MIR3621 FAM69B LOC101930307 C9orf139 C9orf142 FBXW5 PRR31 CLIC3 LOC100128593 CARD9 NPDC1 MAN1B1 SNAPC4 MIR4292
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	PHPT1 LCN8 C9orf172 C9orf163 MIR4674 INPP5E LCN15 PMPCA LCN10 MIR6722 CCDC183 RABL6 NALT1 SDCCAG3 TMEM141 SEC16A FAM69B MIR126 SNORA17B SNHG7 MIR4479 SNORA17A LCN6 TRAF2 AGPAT2 LOC100128593 CARD9 EGFL7 NOTCH1 HSPC324 CCDC183-AS1 GPSM1 DNLZ SNAPC4 MIR4673 LINC01451 EDF1 MAMDC4 MIR4292
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	SAPCD2 FAM166A PHPT1 LCN8 ENTPD2 ABCA2 LCN15 LCN10 EXD3 NELFB TUBB4B UAP1L1 MIR126 DPP7 SNORA17B PTGDS SNHG7 MIR4479 SNORA17A LCN6 TRAF2 LCNL1 TPRN ANAPC2 TMEM210 AGPAT2 TOR4A RNF208 EGFL7 HSPC324 FUT7 CCDC183-AS1 LCN12 LINC01451 EDF1 MAMDC4 TMEM203 RNF224 SSNA1 C9orf172 LRRC26 C8G MAN1B1-AS1 GRIN1 CYSRT1 MIR6722 CCDC183 RABL6 TMEM141 MIR3621 SLC34A3 FAM69B LOC101930307 C9orf139 STPG3 C9orf142 FBXW5 PRR31 CLIC3 NRARP NDOR1 C9orf173-AS1 LOC100128593 NPDC1 MAN1B1 MIR4292

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding