Hs03723042_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136886288 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 EDF1 FBXW5 C9orf172 PHPT1 MIR4479 MIR4292 RABL6 MAMDC4
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	CCDC183 FBXW5 C9orf172 RABL6 LOC100128593 LCNL1 TMEM141 EDF1 PRR31 PHPT1 C9orf142 MIR6722 LCN8 LCN15 ABCA2 LCN10 MIR4292 LCN12 TRAF2 CCDC183-AS1 CLIC3 MIR4479 C8G PTGDS LCN6 MAMDC4
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	ANAPC2 C9orf172 LRRC26 SAPCD2 TOR4A MIR3621 EDF1 SSNA1 SLC34A3 TMEM210 PRR31 C9orf142 NOXA1 FUT7 FAM166A MAN1B1 GRIN1 NSMF NRARP ABCA2 MIR4292 TPRN NPDC1 CYSRT1 CCDC183-AS1 CLIC3 C9orf173-AS1 MAN1B1-AS1 MIR4479 PTGDS RNF224 CCDC183 FBXW5 C9orf139 STPG3 LOC101930307 RABL6 LCNL1 MIR7114 NELFB RNF208 PHPT1 EXD3 NDOR1 ENTPD8 UAP1L1 LCN12 PNPLA7 TRAF2 DPP7 TUBB4B C8G ENTPD2 TMEM203 MAMDC4
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	CCDC183 FAM69B MIR4673 MIR126 C9orf172 EGFL7 DNLZ RABL6 LOC100128593 HSPC324 TMEM141 EDF1 SNORA17B NOTCH1 PHPT1 GPSM1 MIR6722 LCN8 LCN15 INPP5E SNAPC4 LCN10 LINC01451 MIR4292 C9orf163 SDCCAG3 TRAF2 CARD9 CCDC183-AS1 SEC16A AGPAT2 PMPCA SNORA17A MIR4479 SNHG7 MIR4674 LCN6 NALT1 MAMDC4
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	FAM69B C9orf172 LRRC26 SAPCD2 EGFL7 DNLZ MIR3621 LOC100128593 EDF1 SNORA17B NOTCH1 TMEM210 PRR31 C9orf142 FUT7 MAN1B1 GRIN1 INPP5E ABCA2 LCN10 LINC01451 MIR4292 C9orf163 NPDC1 CARD9 CCDC183-AS1 SEC16A CLIC3 SNORA17A MAN1B1-AS1 MIR4479 PTGDS LCN6 CCDC183 FBXW5 C9orf139 MIR4673 MIR126 LOC101930307 RABL6 HSPC324 LCNL1 TMEM141 PHPT1 MIR6722 LCN8 LCN15 SNAPC4 UAP1L1 SDCCAG3 LCN12 TRAF2 DPP7 AGPAT2 PMPCA SNHG7 C8G ENTPD2 MIR4674 NALT1 MAMDC4
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	FAM69B ANAPC2 C9orf172 LRRC26 SAPCD2 EGFL7 TOR4A MIR3621 LOC100128593 EDF1 SSNA1 SLC34A3 SNORA17B TMEM210 PRR31 C9orf142 FUT7 FAM166A MAN1B1 GRIN1 NRARP ABCA2 LCN10 LINC01451 MIR4292 TPRN NPDC1 CYSRT1 CCDC183-AS1 CLIC3 SNORA17A C9orf173-AS1 MAN1B1-AS1 MIR4479 PTGDS LCN6 RNF224 CCDC183 FBXW5 C9orf139 STPG3 MIR126 LOC101930307 RABL6 HSPC324 LCNL1 TMEM141 NELFB RNF208 PHPT1 EXD3 MIR6722 LCN8 NDOR1 LCN15 UAP1L1 LCN12 TRAF2 DPP7 AGPAT2 TUBB4B SNHG7 C8G ENTPD2 TMEM203 MAMDC4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding