Hs03723936_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136891665 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MIR4292 RABL6 PHPT1 EDF1 MAMDC4 MIR4479 TRAF2 FBXW5 C9orf172
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LCNL1 LCN15 ABCA2 TRAF2 C9orf172 MIR4292 C8G CCDC183-AS1 PHPT1 FBXW5 LCN10 LOC100128593 RABL6 EDF1 CCDC183 TMEM141 MIR6722 LCN8 LCN6 LCN12 PTGDS CLIC3 MAMDC4 MIR4479 C9orf142 PRR31
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	UAP1L1 MAN1B1-AS1 STPG3 TRAF2 SLC34A3 MIR4292 CCDC183-AS1 MAN1B1 NRARP PHPT1 SAPCD2 PNPLA7 FBXW5 FUT7 NDOR1 RNF208 RABL6 EDF1 ANAPC2 TOR4A LRRC26 C9orf173-AS1 NOXA1 GRIN1 CLIC3 DPP7 MAMDC4 ENTPD2 RNF224 MIR4479 C9orf142 LCNL1 MIR7114 ABCA2 NELFB ENTPD8 C9orf172 C8G TMEM210 SSNA1 TUBB4B MIR3621 LOC101930307 EXD3 C9orf139 NPDC1 CCDC183 NSMF TPRN TMEM203 LCN12 PTGDS CYSRT1 FAM166A PRR31
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	MIR4673 LCN15 HSPC324 GPSM1 TRAF2 C9orf172 FAM69B DNLZ CARD9 EGFL7 SNHG7 MIR4292 CCDC183-AS1 SNORA17B SEC16A PHPT1 NALT1 SNAPC4 LCN10 PMPCA LOC100128593 RABL6 SDCCAG3 EDF1 AGPAT2 SNORA17A CCDC183 C9orf163 TMEM141 INPP5E LINC01451 NOTCH1 MIR126 MIR6722 LCN8 LCN6 MAMDC4 MIR4479 MIR4674
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	UAP1L1 MAN1B1-AS1 TRAF2 FAM69B DNLZ CARD9 EGFL7 SNHG7 MIR4292 CCDC183-AS1 SNORA17B SEC16A MAN1B1 PHPT1 SAPCD2 FBXW5 FUT7 LCN10 LOC100128593 RABL6 SDCCAG3 EDF1 SNORA17A C9orf163 TMEM141 NOTCH1 LRRC26 MIR126 LCN8 LCN6 GRIN1 CLIC3 DPP7 MAMDC4 ENTPD2 MIR4479 C9orf142 LCNL1 MIR4673 LCN15 ABCA2 HSPC324 C9orf172 C8G TMEM210 MIR3621 NALT1 SNAPC4 LOC101930307 PMPCA C9orf139 AGPAT2 NPDC1 CCDC183 INPP5E LINC01451 MIR6722 LCN12 PTGDS MIR4674 PRR31
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	UAP1L1 MAN1B1-AS1 STPG3 TRAF2 FAM69B SLC34A3 EGFL7 SNHG7 MIR4292 CCDC183-AS1 SNORA17B MAN1B1 NRARP PHPT1 SAPCD2 FBXW5 FUT7 NDOR1 LCN10 RNF208 LOC100128593 RABL6 EDF1 ANAPC2 SNORA17A TMEM141 TOR4A LRRC26 MIR126 C9orf173-AS1 LCN8 LCN6 GRIN1 CLIC3 DPP7 MAMDC4 ENTPD2 RNF224 MIR4479 C9orf142 LCNL1 LCN15 ABCA2 NELFB HSPC324 C9orf172 C8G TMEM210 SSNA1 TUBB4B MIR3621 LOC101930307 EXD3 C9orf139 AGPAT2 NPDC1 CCDC183 LINC01451 TPRN TMEM203 MIR6722 LCN12 PTGDS CYSRT1 FAM166A PRR31

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding