Hs03723936_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136891665 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 PHPT1 C9orf172 EDF1 MIR4479 FBXW5 MAMDC4 MIR4292 RABL6
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	TMEM141 C9orf142 TRAF2 PHPT1 MIR4479 LCN10 LCNL1 LCN12 CLIC3 C9orf172 EDF1 LCN6 LCN8 PTGDS LCN15 C8G FBXW5 MAMDC4 RABL6 PRR31 ABCA2 CCDC183-AS1 LOC100128593 MIR6722 MIR4292 CCDC183
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	PNPLA7 NELFB ENTPD8 UAP1L1 C9orf139 SSNA1 MIR3621 NDOR1 LRRC26 SAPCD2 LCNL1 LCN12 ANAPC2 TOR4A TMEM210 C9orf173-AS1 C8G DPP7 PRR31 TUBB4B CYSRT1 MAN1B1 TPRN ABCA2 STPG3 GRIN1 MIR7114 TMEM203 NRARP CCDC183 EXD3 NOXA1 C9orf142 TRAF2 PHPT1 FAM166A RNF224 MIR4479 LOC101930307 RNF208 NPDC1 CLIC3 C9orf172 EDF1 ENTPD2 PTGDS MAN1B1-AS1 FBXW5 MAMDC4 RABL6 SLC34A3 NSMF CCDC183-AS1 MIR4292 FUT7
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	TMEM141 MIR126 UAP1L1 MIR4673 HSPC324 C9orf139 MIR3621 INPP5E LRRC26 SAPCD2 LCNL1 LCN12 AGPAT2 LCN6 LINC01451 TMEM210 EGFL7 C8G DPP7 PRR31 NOTCH1 MAN1B1 ABCA2 GRIN1 PMPCA SEC16A LOC100128593 SNHG7 CCDC183 C9orf142 TRAF2 PHPT1 FAM69B MIR4479 LCN10 DNLZ CARD9 LOC101930307 MIR4674 NPDC1 SDCCAG3 CLIC3 C9orf172 NALT1 EDF1 ENTPD2 SNORA17A LCN8 PTGDS SNORA17B SNAPC4 C9orf163 MAN1B1-AS1 LCN15 FBXW5 MAMDC4 RABL6 CCDC183-AS1 MIR6722 MIR4292 FUT7
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	TMEM141 MIR126 TRAF2 MIR4673 PHPT1 HSPC324 FAM69B MIR4479 INPP5E LCN10 DNLZ CARD9 MIR4674 SDCCAG3 AGPAT2 C9orf172 NALT1 EDF1 SNORA17A LCN6 LINC01451 LCN8 SNORA17B EGFL7 SNAPC4 C9orf163 LCN15 GPSM1 MAMDC4 RABL6 NOTCH1 PMPCA SEC16A CCDC183-AS1 LOC100128593 MIR6722 MIR4292 SNHG7 CCDC183
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	TMEM141 MIR126 NELFB UAP1L1 HSPC324 C9orf139 SSNA1 MIR3621 NDOR1 LRRC26 SAPCD2 LCNL1 LCN12 AGPAT2 ANAPC2 LCN6 LINC01451 TOR4A TMEM210 EGFL7 C9orf173-AS1 C8G DPP7 PRR31 TUBB4B CYSRT1 MAN1B1 TPRN ABCA2 STPG3 GRIN1 TMEM203 LOC100128593 NRARP SNHG7 CCDC183 EXD3 C9orf142 TRAF2 PHPT1 FAM69B FAM166A RNF224 MIR4479 LCN10 LOC101930307 RNF208 NPDC1 CLIC3 C9orf172 EDF1 ENTPD2 SNORA17A LCN8 PTGDS SNORA17B MAN1B1-AS1 LCN15 FBXW5 MAMDC4 RABL6 SLC34A3 CCDC183-AS1 MIR6722 MIR4292 FUT7

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding