Hs03725602_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136885941 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MIR4479 RABL6 C9orf172 PHPT1 FBXW5 MAMDC4 MIR4292 TRAF2 EDF1
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	MIR4479 PHPT1 MIR6722 TRAF2 PRR31 C8G LCN8 CLIC3 MAMDC4 CCDC183 MIR4292 LCN15 EDF1 RABL6 TMEM141 LCN12 FBXW5 ABCA2 PTGDS CCDC183-AS1 LCNL1 LOC100128593 C9orf172 LCN6 LCN10 C9orf142
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	CYSRT1 PHPT1 NRARP C9orf173-AS1 TMEM203 MIR3621 ANAPC2 NELFB DPP7 RNF208 NPDC1 CLIC3 MAMDC4 CCDC183 MIR4292 FUT7 GRIN1 RNF224 RABL6 LCN12 MAN1B1-AS1 PTGDS C9orf172 PNPLA7 EXD3 TOR4A C9orf142 NSMF MIR4479 NOXA1 UAP1L1 SAPCD2 SLC34A3 TRAF2 PRR31 TPRN TMEM210 C8G ENTPD8 LRRC26 EDF1 NDOR1 FBXW5 ABCA2 CCDC183-AS1 FAM166A MIR7114 LOC101930307 C9orf139 LCNL1 TUBB4B ENTPD2 SSNA1 MAN1B1 STPG3
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	PHPT1 MIR6722 NALT1 MIR3621 MIR126 DPP7 NPDC1 CLIC3 MAMDC4 CCDC183 MIR4292 FUT7 GRIN1 LCN15 INPP5E EGFL7 RABL6 LCN12 MAN1B1-AS1 PTGDS DNLZ LOC100128593 C9orf163 C9orf172 MIR4673 LCN6 LINC01451 C9orf142 AGPAT2 MIR4479 UAP1L1 SEC16A SAPCD2 CARD9 NOTCH1 TRAF2 PRR31 SNHG7 TMEM210 SNORA17B C8G LCN8 LRRC26 EDF1 TMEM141 FBXW5 ABCA2 CCDC183-AS1 SNAPC4 LOC101930307 C9orf139 LCNL1 ENTPD2 SDCCAG3 SNORA17A PMPCA MAN1B1 FAM69B MIR4674 HSPC324 LCN10
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	MIR4479 PHPT1 MIR6722 SEC16A NALT1 CARD9 NOTCH1 TRAF2 SNHG7 SNORA17B MIR126 LCN8 MAMDC4 CCDC183 MIR4292 LCN15 EDF1 INPP5E EGFL7 RABL6 TMEM141 CCDC183-AS1 SNAPC4 GPSM1 DNLZ SDCCAG3 LOC100128593 SNORA17A PMPCA C9orf163 C9orf172 MIR4673 LCN6 FAM69B MIR4674 HSPC324 LCN10 LINC01451 AGPAT2
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	CYSRT1 PHPT1 MIR6722 NRARP C9orf173-AS1 TMEM203 MIR3621 MIR126 ANAPC2 NELFB DPP7 RNF208 NPDC1 CLIC3 MAMDC4 CCDC183 MIR4292 FUT7 GRIN1 LCN15 EGFL7 RNF224 RABL6 LCN12 MAN1B1-AS1 PTGDS LOC100128593 C9orf172 LCN6 LINC01451 EXD3 TOR4A C9orf142 AGPAT2 MIR4479 UAP1L1 SAPCD2 SLC34A3 TRAF2 PRR31 SNHG7 TPRN TMEM210 SNORA17B C8G LCN8 LRRC26 EDF1 NDOR1 TMEM141 FBXW5 ABCA2 CCDC183-AS1 FAM166A LOC101930307 C9orf139 LCNL1 TUBB4B ENTPD2 SSNA1 SNORA17A MAN1B1 FAM69B HSPC324 LCN10 STPG3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding