Hs03725602_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136885941 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 RABL6 C9orf172 EDF1 FBXW5 MAMDC4 MIR4479 MIR4292 PHPT1
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	RABL6 LCNL1 C9orf172 LOC100128593 LCN8 ABCA2 MAMDC4 PRR31 C9orf142 LCN15 EDF1 LCN10 CCDC183 TMEM141 MIR6722 CLIC3 PTGDS PHPT1 LCN12 FBXW5 C8G TRAF2 LCN6 CCDC183-AS1 MIR4479 MIR4292
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	TOR4A C9orf172 LRRC26 ABCA2 EXD3 MAMDC4 NSMF C9orf142 DPP7 NELFB CYSRT1 TMEM203 C9orf139 CLIC3 PTGDS NOXA1 LCN12 RNF224 GRIN1 SSNA1 NDOR1 MAN1B1 C8G FUT7 TRAF2 TUBB4B PNPLA7 ENTPD8 MIR4292 RABL6 LCNL1 ENTPD2 MAN1B1-AS1 C9orf173-AS1 MIR7114 ANAPC2 PRR31 FAM166A RNF208 UAP1L1 EDF1 CCDC183 SAPCD2 LOC101930307 TPRN TMEM210 PHPT1 NRARP MIR3621 FBXW5 NPDC1 SLC34A3 CCDC183-AS1 STPG3 MIR4479
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	RABL6 C9orf172 LOC100128593 C9orf163 SDCCAG3 MIR126 LCN8 MAMDC4 SNORA17A SEC16A LCN15 EDF1 LCN10 CCDC183 GPSM1 TMEM141 MIR6722 AGPAT2 PHPT1 INPP5E SNAPC4 FAM69B LINC01451 EGFL7 NOTCH1 PMPCA CARD9 TRAF2 SNORA17B MIR4674 DNLZ MIR4673 NALT1 LCN6 SNHG7 CCDC183-AS1 HSPC324 MIR4479 MIR4292
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	C9orf172 LOC100128593 C9orf163 SDCCAG3 LRRC26 ABCA2 MAMDC4 C9orf142 DPP7 SEC16A LCN15 LCN10 C9orf139 MIR6722 CLIC3 PTGDS LCN12 GRIN1 INPP5E SNAPC4 MAN1B1 C8G PMPCA CARD9 FUT7 TRAF2 NALT1 MIR4292 RABL6 LCNL1 ENTPD2 MAN1B1-AS1 MIR126 LCN8 PRR31 SNORA17A UAP1L1 EDF1 CCDC183 SAPCD2 TMEM141 LOC101930307 TMEM210 AGPAT2 PHPT1 FAM69B LINC01451 MIR3621 EGFL7 FBXW5 NOTCH1 NPDC1 SNORA17B MIR4674 DNLZ MIR4673 LCN6 SNHG7 CCDC183-AS1 HSPC324 MIR4479
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	TOR4A C9orf172 LOC100128593 LRRC26 ABCA2 EXD3 MAMDC4 C9orf142 DPP7 NELFB CYSRT1 LCN15 LCN10 TMEM203 C9orf139 MIR6722 CLIC3 PTGDS LCN12 RNF224 GRIN1 SSNA1 NDOR1 MAN1B1 C8G FUT7 TRAF2 TUBB4B MIR4292 RABL6 LCNL1 ENTPD2 MAN1B1-AS1 C9orf173-AS1 MIR126 LCN8 ANAPC2 PRR31 SNORA17A FAM166A RNF208 UAP1L1 EDF1 CCDC183 SAPCD2 TMEM141 LOC101930307 TPRN TMEM210 AGPAT2 PHPT1 NRARP FAM69B LINC01451 MIR3621 EGFL7 FBXW5 NPDC1 SNORA17B LCN6 SNHG7 SLC34A3 CCDC183-AS1 HSPC324 STPG3 MIR4479

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding