Hs03733171_cn

• Gene Symbol: BTRC
• Assay Reference Genome Location: Chr.10:101364057 on build GRCh38
• Cytoband: 10q24.32

Target Gene Details

• Entrez Gene ID: 8945
• Gene Name: beta-transducin repeat containing E3 ubiquitin protein ligase
• Gene Aliases: BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP
• Location: Chr.10:101353808-101557321 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BTRC	NM_001256856.1			NP_001243785.1
	NM_003939.4			NP_003930.1
	NM_033637.3			NP_378663.1
	XM_006718054.2			XP_006718117.1
	XM_017016870.1			XP_016872359.1
	XM_017016872.1			XP_016872361.1
	XM_017016874.1			XP_016872363.1
	AF101784.1			AAD08702.1
	AF129530.1			AAF04464.1
	AK295870.1
	AK313353.1
	AK313417.1
	AL707686.1
	AY207475.1			AAO59171.1
	AY207476.1			AAO59172.1
	BC027994.1			AAH27994.1
	CR749295.1			CAH18150.1
	DA218668.1
	GU727631.1
	KU178451.1
	KU178452.1
	KU178453.1
	KU178454.1
	Y14153.1			CAA74572.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv964n100	Chr.10:101363048 - 101579801 on Build GRCh38	Gain	POLL BTRC
esv2750847	Chr.10:101295225 - 101692888 on Build GRCh38	Gain	DPCD MIR3158-1 MIR3158-2 POLL FBXW4 BTRC

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
protein dephosphorylation
ubiquitin-dependent protein catabolic process
signal transduction
viral process
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein destabilization
mammary gland epithelial cell proliferation
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of circadian rhythm
regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of proteolysis
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
T cell receptor signaling pathway
stress-activated MAPK cascade
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
branching involved in mammary gland duct morphogenesis
regulation of canonical Wnt signaling pathway
regulation of proteasomal protein catabolic process
cellular response to organic cyclic compound

Function(s)

ubiquitin-protein transferase activity
protein binding
beta-catenin binding
ligase activity
protein phosphorylated amino acid binding
protein dimerization activity
ubiquitin protein ligase activity