Hs03735507_cn

• Gene Symbol: NKX6-2
• Assay Reference Genome Location: Chr.10:132783855 on build GRCh38
• Cytoband: 10q26.3

Target Gene Details

• Entrez Gene ID: 84504
• Gene Name: NK6 homeobox 2
• Gene Aliases: GTX, NKX6.2, NKX6B
• Location: Chr.10:132783179-132786033 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NKX6-2	XM_017016789.1			XP_016872278.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv552528	Chr.10:132738227 - 132803137 on Build GRCh38	Gain	INPP5A NKX6-2
nsv832033	Chr.10:132743736 - 132870955 on Build GRCh38	Loss	INPP5A NKX6-2 CFAP46
dgv183n67	Chr.10:132765626 - 132808425 on Build GRCh38	Gain	INPP5A NKX6-2 CFAP46
nsv552526	Chr.10:132699017 - 133103793 on Build GRCh38	Gain	LINC01167 ADGRA1 LINC01166 LINC01168 ADGRA1-AS1 INPP5A NKX6-2 CFAP46
nsv825660	Chr.10:132778084 - 132801878 on Build GRCh38	Gain	INPP5A NKX6-2
nsv470977	Chr.10:132699016 - 132814378 on Build GRCh38	Loss	INPP5A NKX6-2 CFAP46
nsv952700	Chr.10:132702797 - 132851596 on Build GRCh38	Deletion	INPP5A NKX6-2 CFAP46
nsv825663	Chr.10:132782861 - 132789273 on Build GRCh38	Gain	INPP5A NKX6-2
esv3577894	Chr.10:132744696 - 132825790 on Build GRCh38	Gain	INPP5A NKX6-2 CFAP46
nsv1054934	Chr.10:130334322 - 133158679 on Build GRCh38	Gain	LINC01167 LOC105378568 LINC01164 LRRC27 JAKMIP3 NKX6-2 CFAP46 PWWP2B ADGRA1 TCERG1L-AS1 STK32C LINC01166 PPP2R2D MIR378C LINC01168 TCERG1L LOC107984282 ADGRA1-AS1 DPYSL4 BNIP3 C10orf91 INPP5A
nsv832034	Chr.10:132761541 - 132940326 on Build GRCh38	Loss	INPP5A NKX6-2 CFAP46
nsv509378	Chr.10:132737773 - 132833305 on Build GRCh38	Insertion	INPP5A NKX6-2 CFAP46
nsv832032	Chr.10:132648722 - 132851966 on Build GRCh38	Loss	INPP5A NKX6-2 CFAP46
dgv184n67	Chr.10:132782425 - 132794098 on Build GRCh38	Gain	INPP5A NKX6-2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

homeodomain transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of cell fate commitment
positive regulation of cell fate commitment
regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
central nervous system myelination
endocrine pancreas development
negative regulation of glial cell differentiation
positive regulation of glial cell differentiation
neuromuscular process controlling balance

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding