Hs03781723_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:415453 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	LRRC56 B4GALNT4 IFITM1 SIGIRR RNH1 CDHR5 IFITM2 IFITM3 HRAS LMNTD2 PGGHG IFITM5 ANO9 IRF7 MIR210HG PHRF1 RASSF7 PTDSS2 LOC101059906 LOC143666 MIR210 PKP3
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	LRRC56 PANO1 B4GALNT4 TALDO1 LOC171391 SIGIRR RNH1 DRD4 AP2A2 CDHR5 PNPLA2 TMEM80 LMNTD2 MUC5B TOLLIP RPLP2 SNORA52 DEAF1 IRF7 MIR210HG PDDC1 RASSF7 LOC101059906 CHID1 PIDD1 MIR6744 EPS8L2 MUC6 SLC25A22 CRACR2B TSPAN4 POLR2L HRAS MUC5AC ANO9 PHRF1 PTDSS2 MUC2 SCT CD151 LOC143666 LOC101927503 MIR210 CEND1 PKP3
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	B4GALNT4 ANO9 SIGIRR PKP3
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	ANO9 SIGIRR
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	ANO9 SIGIRR
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	LRRC56 PANO1 TALDO1 LOC171391 SIGIRR RNH1 DRD4 AP2A2 CDHR5 PNPLA2 TMEM80 LMNTD2 MUC5B TOLLIP RPLP2 SNORA52 DEAF1 IRF7 MIR210HG PDDC1 RASSF7 LOC101059906 CHID1 PIDD1 MIR6744 EPS8L2 MUC6 SLC25A22 CRACR2B TSPAN4 POLR2L HRAS MUC5AC ANO9 PHRF1 PTDSS2 TOLLIP-AS1 MUC2 SCT CD151 LOC143666 LOC101927503 MIR210 CEND1
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	ANO9 SIGIRR
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	B4GALNT4 ANO9 PTDSS2 SIGIRR RNH1 PKP3
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	B4GALNT4 ANO9 SIGIRR PKP3
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	ODF3 B4GALNT4 BET1L IFITM1 SIGIRR IFITM2 IFITM3 RIC8A PGGHG NLRP6 PSMD13 IFITM5 ANO9 MIR6743 PTDSS2 SIRT3 PKP3
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	B4GALNT4 ANO9 PTDSS2 SIGIRR PKP3
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	LRRC56 PANO1 B4GALNT4 TALDO1 LOC171391 SIGIRR RNH1 DRD4 AP2A2 CDHR5 PNPLA2 TMEM80 LMNTD2 RPLP2 SNORA52 DEAF1 IRF7 MIR210HG PDDC1 RASSF7 LOC101059906 CHID1 PIDD1 EPS8L2 SLC25A22 CRACR2B TSPAN4 POLR2L HRAS ANO9 PHRF1 PTDSS2 SCT CD151 LOC143666 MIR210 CEND1 PKP3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding