Hs03781723_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:415453 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	LOC101059906 CDHR5 LOC143666 IRF7 PTDSS2 LRRC56 PKP3 MIR210HG LMNTD2 IFITM5 IFITM2 PGGHG IFITM1 MIR210 RASSF7 SIGIRR HRAS ANO9 RNH1 PHRF1 IFITM3 B4GALNT4
nsv467633	Chr.11:366710 - 432436 on Build GRCh38	Loss	SIGIRR ANO9 PKP3 B4GALNT4
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	LOC101059906 PANO1 AP2A2 IRF7 PTDSS2 MUC6 EPS8L2 LOC101927503 RPLP2 LRRC56 PIDD1 MUC5AC PKP3 LOC171391 RASSF7 PDDC1 PNPLA2 HRAS ANO9 SLC25A22 TALDO1 MIR6744 CRACR2B POLR2L SCT CEND1 CD151 TOLLIP CDHR5 LOC143666 MUC2 MUC5B DRD4 MIR210HG LMNTD2 MIR210 TMEM80 SNORA52 SIGIRR CHID1 TSPAN4 RNH1 DEAF1 PHRF1 B4GALNT4
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	SIGIRR ANO9
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	SIGIRR ANO9
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	LOC101059906 PANO1 AP2A2 IRF7 PTDSS2 MUC6 EPS8L2 LOC101927503 RPLP2 LRRC56 PIDD1 MUC5AC LOC171391 RASSF7 PDDC1 PNPLA2 HRAS ANO9 SLC25A22 TALDO1 MIR6744 CRACR2B POLR2L SCT CEND1 CD151 TOLLIP CDHR5 LOC143666 MUC2 MUC5B DRD4 MIR210HG LMNTD2 MIR210 TMEM80 SNORA52 SIGIRR CHID1 TSPAN4 TOLLIP-AS1 RNH1 DEAF1 PHRF1
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	SIGIRR ANO9
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	SIGIRR ANO9 PKP3 B4GALNT4
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	SIGIRR PTDSS2 ANO9 RNH1 PKP3 B4GALNT4
dgv1012n100	Chr.11:198510 - 427836 on Build GRCh38	Gain	ODF3 BET1L MIR6743 PKP3 IFITM5 IFITM2 NLRP6 PGGHG IFITM1 SIGIRR RIC8A ANO9 PSMD13 IFITM3 SIRT3 B4GALNT4
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	SIGIRR PTDSS2 ANO9 PKP3 B4GALNT4
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	LOC101059906 PANO1 AP2A2 IRF7 PTDSS2 EPS8L2 RPLP2 LRRC56 PIDD1 PKP3 LOC171391 RASSF7 PDDC1 PNPLA2 HRAS ANO9 SLC25A22 TALDO1 CRACR2B POLR2L SCT CEND1 CD151 CDHR5 LOC143666 DRD4 MIR210HG LMNTD2 MIR210 TMEM80 SNORA52 SIGIRR CHID1 TSPAN4 RNH1 DEAF1 PHRF1 B4GALNT4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding