Hs03786585_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:415972 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	RASSF7 LRRC56 PKP3 IFITM3 HRAS B4GALNT4 ANO9 MIR210HG LOC101059906 IFITM5 IRF7 IFITM1 PGGHG PTDSS2 LMNTD2 RNH1 CDHR5 LOC143666 PHRF1 MIR210 IFITM2 SIGIRR
nsv467633	Chr.11:366710 - 432436 on Build GRCh38	Loss	PKP3 B4GALNT4 ANO9 SIGIRR
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	DRD4 CHID1 LRRC56 PNPLA2 MUC5B CEND1 CRACR2B MIR210HG PDDC1 TALDO1 DEAF1 LOC171391 MUC2 PTDSS2 PIDD1 CD151 RNH1 TMEM80 AP2A2 TOLLIP RPLP2 LOC143666 PHRF1 EPS8L2 LOC101927503 RASSF7 PKP3 SCT HRAS B4GALNT4 ANO9 LOC101059906 IRF7 MUC6 TSPAN4 SLC25A22 LMNTD2 PANO1 MIR6744 CDHR5 SNORA52 POLR2L MUC5AC MIR210 SIGIRR
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	ANO9 SIGIRR
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	ANO9 SIGIRR
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	DRD4 CHID1 LRRC56 PNPLA2 MUC5B CEND1 CRACR2B MIR210HG PDDC1 TALDO1 DEAF1 LOC171391 MUC2 PTDSS2 PIDD1 CD151 RNH1 TMEM80 AP2A2 TOLLIP RPLP2 LOC143666 PHRF1 EPS8L2 LOC101927503 RASSF7 SCT HRAS ANO9 LOC101059906 IRF7 MUC6 TSPAN4 SLC25A22 LMNTD2 PANO1 TOLLIP-AS1 MIR6744 CDHR5 SNORA52 POLR2L MUC5AC MIR210 SIGIRR
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	ANO9 SIGIRR
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	PKP3 B4GALNT4 ANO9 SIGIRR
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	PTDSS2 PKP3 RNH1 B4GALNT4 ANO9 SIGIRR
dgv1012n100	Chr.11:198510 - 427836 on Build GRCh38	Gain	MIR6743 PKP3 BET1L IFITM3 B4GALNT4 SIRT3 ANO9 IFITM5 IFITM1 PGGHG PSMD13 ODF3 RIC8A NLRP6 IFITM2 SIGIRR
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	PTDSS2 PKP3 B4GALNT4 ANO9 SIGIRR
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	DRD4 CHID1 LRRC56 PNPLA2 CEND1 CRACR2B MIR210HG PDDC1 TALDO1 DEAF1 LOC171391 PTDSS2 PIDD1 CD151 RNH1 TMEM80 AP2A2 RPLP2 LOC143666 PHRF1 EPS8L2 RASSF7 PKP3 SCT HRAS B4GALNT4 ANO9 LOC101059906 IRF7 TSPAN4 SLC25A22 LMNTD2 PANO1 CDHR5 SNORA52 POLR2L MIR210 SIGIRR

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding