Hs03798560_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:416440 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	SIGIRR ANO9
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	RPLP2 LOC143666 PANO1 LMNTD2 MIR210HG MIR6744 IRF7 CDHR5 POLR2L PTDSS2 CRACR2B SIGIRR MUC2 TOLLIP-AS1 RASSF7 SCT TMEM80 AP2A2 RNH1 MUC6 LOC101059906 TALDO1 SLC25A22 ANO9 EPS8L2 MIR210 LOC101927503 DEAF1 HRAS MUC5AC CEND1 PNPLA2 LRRC56 CD151 TSPAN4 TOLLIP MUC5B DRD4 PIDD1 PDDC1 PHRF1 LOC171391 SNORA52 CHID1
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	SIGIRR ANO9
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	RNH1 PTDSS2 SIGIRR ANO9 PKP3 B4GALNT4
dgv1012n100	Chr.11:198510 - 427836 on Build GRCh38	Gain	IFITM3 ANO9 PSMD13 ODF3 B4GALNT4 NLRP6 IFITM1 PGGHG BET1L SIRT3 SIGIRR PKP3 IFITM2 RIC8A IFITM5 MIR6743
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	PTDSS2 SIGIRR ANO9 PKP3 B4GALNT4
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	RPLP2 LOC143666 PANO1 LMNTD2 MIR210HG B4GALNT4 IRF7 CDHR5 POLR2L PTDSS2 CRACR2B SIGIRR PKP3 RASSF7 SCT TMEM80 AP2A2 RNH1 LOC101059906 TALDO1 SLC25A22 ANO9 EPS8L2 MIR210 DEAF1 HRAS CEND1 PNPLA2 LRRC56 CD151 TSPAN4 DRD4 PIDD1 PDDC1 PHRF1 LOC171391 SNORA52 CHID1
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	RNH1 IFITM3 LOC101059906 ANO9 MIR210 LOC143666 HRAS LMNTD2 MIR210HG B4GALNT4 IFITM1 PGGHG IRF7 CDHR5 LRRC56 PTDSS2 SIGIRR PKP3 PHRF1 RASSF7 IFITM2 IFITM5
nsv467633	Chr.11:366710 - 432436 on Build GRCh38	Loss	SIGIRR ANO9 PKP3 B4GALNT4
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	RPLP2 LOC143666 PANO1 LMNTD2 MIR210HG B4GALNT4 MIR6744 IRF7 CDHR5 POLR2L PTDSS2 CRACR2B SIGIRR MUC2 PKP3 RASSF7 SCT TMEM80 AP2A2 RNH1 MUC6 LOC101059906 TALDO1 SLC25A22 ANO9 EPS8L2 MIR210 LOC101927503 DEAF1 HRAS MUC5AC CEND1 PNPLA2 LRRC56 CD151 TSPAN4 TOLLIP MUC5B DRD4 PIDD1 PDDC1 PHRF1 LOC171391 SNORA52 CHID1
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	SIGIRR ANO9
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	SIGIRR ANO9 PKP3 B4GALNT4
nsv1143665	Chr.11:416400 - 417400 on Build GRCh38	Deletion	SIGIRR

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding