Hs03798560_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:416440 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_021805.2			NP_068577.2
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	DA963481.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	SIGIRR ANO9
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	RNH1 PTDSS2 POLR2L CD151 CRACR2B LOC143666 SCT PNPLA2 LMNTD2 LOC171391 IRF7 EPS8L2 AP2A2 TOLLIP SLC25A22 TMEM80 PDDC1 RASSF7 CEND1 MUC2 RPLP2 CHID1 CDHR5 TSPAN4 PIDD1 LOC101059906 MUC5B TALDO1 PANO1 LRRC56 SIGIRR MIR6744 PHRF1 LOC101927503 SNORA52 MIR210 TOLLIP-AS1 HRAS DEAF1 MUC6 MIR210HG ANO9 DRD4 MUC5AC
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	SIGIRR ANO9
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	SIGIRR RNH1 PTDSS2 PKP3 ANO9 B4GALNT4
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	ODF3 PTDSS2 IFITM5 BET1L IFITM1 RIC8A B4GALNT4 SIGIRR PKP3 PSMD13 IFITM2 MIR6743 ANO9 PGGHG SIRT3 IFITM3 NLRP6
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	SIGIRR PTDSS2 PKP3 ANO9 B4GALNT4
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	RNH1 PTDSS2 POLR2L CD151 CRACR2B LOC143666 SCT PNPLA2 LMNTD2 LOC171391 IRF7 EPS8L2 AP2A2 SLC25A22 TMEM80 PDDC1 RASSF7 CEND1 RPLP2 CHID1 CDHR5 TSPAN4 B4GALNT4 PIDD1 LOC101059906 TALDO1 PANO1 LRRC56 SIGIRR PHRF1 SNORA52 MIR210 PKP3 HRAS DEAF1 MIR210HG ANO9 DRD4
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	RNH1 PTDSS2 IFITM5 IFITM1 CDHR5 LOC143666 B4GALNT4 LOC101059906 LRRC56 SIGIRR PHRF1 LMNTD2 IRF7 MIR210 PKP3 HRAS IFITM2 MIR210HG ANO9 PGGHG IFITM3 RASSF7
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	RNH1 PTDSS2 POLR2L CD151 CRACR2B LOC143666 SCT PNPLA2 LMNTD2 LOC171391 IRF7 EPS8L2 AP2A2 TOLLIP SLC25A22 TMEM80 PDDC1 RASSF7 CEND1 MUC2 RPLP2 CHID1 CDHR5 TSPAN4 B4GALNT4 PIDD1 LOC101059906 MUC5B TALDO1 PANO1 LRRC56 SIGIRR MIR6744 PHRF1 LOC101927503 SNORA52 MIR210 PKP3 HRAS DEAF1 MUC6 MIR210HG ANO9 DRD4 MUC5AC
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	SIGIRR PKP3 ANO9 B4GALNT4
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	SIGIRR ANO9
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	SIGIRR PKP3 ANO9 B4GALNT4
nsv1143665	Chr.11:416400 - 417400 on Build GRCh38	Deletion	SIGIRR

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding