Hs03805183_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:412936 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_001135054.1			NP_001128526.1
	NM_021805.2			NP_068577.2
	XM_005253044.2			XP_005253101.1
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	XM_005253048.4			XP_005253105.1
	XM_017018099.1			XP_016873588.1
	XM_017018100.1			XP_016873589.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	BC106007.1			AAI06008.1
	DA963481.1
	DB112269.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	ANO9 SIGIRR
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	POLR2L MIR210HG CDHR5 EPS8L2 SNORA52 MUC5B PDDC1 CEND1 LMNTD2 MUC6 TMEM80 TOLLIP-AS1 RASSF7 PTDSS2 TSPAN4 MIR210 LRRC56 LOC101927503 LOC171391 DRD4 PNPLA2 RPLP2 PIDD1 CHID1 SLC25A22 LOC101059906 IRF7 HRAS MUC2 AP2A2 MIR6744 SCT RNH1 DEAF1 CD151 PANO1 TALDO1 ANO9 CRACR2B SIGIRR TOLLIP PHRF1 LOC143666 MUC5AC
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	ANO9 SIGIRR
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	RNH1 B4GALNT4 PTDSS2 ANO9 SIGIRR PKP3
dgv1012n100	Chr.11:198510 - 427836 on Build GRCh38	Gain	B4GALNT4 BET1L PGGHG RIC8A MIR6743 IFITM1 ANO9 SIGIRR PSMD13 SIRT3 IFITM2 PKP3 ODF3 NLRP6 IFITM3 IFITM5
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	B4GALNT4 PTDSS2 ANO9 SIGIRR PKP3
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	POLR2L MIR210HG CDHR5 EPS8L2 SNORA52 PDDC1 CEND1 LMNTD2 TMEM80 RASSF7 PTDSS2 TSPAN4 MIR210 LRRC56 LOC171391 DRD4 PNPLA2 RPLP2 PIDD1 CHID1 B4GALNT4 SLC25A22 LOC101059906 IRF7 HRAS AP2A2 SCT RNH1 DEAF1 CD151 PANO1 TALDO1 ANO9 CRACR2B SIGIRR PKP3 PHRF1 LOC143666
nsv1070918	Chr.11:410499 - 414500 on Build GRCh38	Deletion	SIGIRR
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	B4GALNT4 PGGHG LOC101059906 MIR210HG CDHR5 IRF7 HRAS LMNTD2 RNH1 RASSF7 PTDSS2 MIR210 LRRC56 IFITM1 ANO9 SIGIRR IFITM2 PKP3 IFITM3 PHRF1 IFITM5 LOC143666
nsv467633	Chr.11:366710 - 432436 on Build GRCh38	Loss	B4GALNT4 ANO9 SIGIRR PKP3
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	POLR2L MIR210HG CDHR5 EPS8L2 SNORA52 MUC5B PDDC1 CEND1 LMNTD2 MUC6 TMEM80 RASSF7 PTDSS2 TSPAN4 MIR210 LRRC56 LOC101927503 LOC171391 DRD4 PNPLA2 RPLP2 PIDD1 CHID1 B4GALNT4 SLC25A22 LOC101059906 IRF7 HRAS MUC2 AP2A2 MIR6744 SCT RNH1 DEAF1 CD151 PANO1 TALDO1 ANO9 CRACR2B SIGIRR PKP3 TOLLIP PHRF1 LOC143666 MUC5AC
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	ANO9 SIGIRR
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	B4GALNT4 ANO9 SIGIRR PKP3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding