Hs03805183_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:412936 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_001135054.1			NP_001128526.1
	NM_021805.2			NP_068577.2
	XM_005253044.2			XP_005253101.1
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	XM_005253048.4			XP_005253105.1
	XM_017018099.1			XP_016873588.1
	XM_017018100.1			XP_016873589.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	BC106007.1			AAI06008.1
	DA963481.1
	DB112269.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	SIGIRR ANO9
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	MUC5B MIR6744 SLC25A22 LMNTD2 RASSF7 SNORA52 MUC5AC MIR210 TOLLIP CEND1 PNPLA2 POLR2L PTDSS2 RNH1 MUC6 MUC2 TSPAN4 HRAS PANO1 SIGIRR DRD4 PIDD1 LOC101927503 TMEM80 MIR210HG LOC143666 PDDC1 LOC171391 PHRF1 EPS8L2 LOC101059906 TOLLIP-AS1 SCT CRACR2B DEAF1 LRRC56 TALDO1 IRF7 ANO9 CDHR5 RPLP2 CHID1 CD151 AP2A2
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	SIGIRR ANO9
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	PTDSS2 RNH1 B4GALNT4 SIGIRR ANO9 PKP3
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	NLRP6 B4GALNT4 BET1L IFITM2 PKP3 RIC8A IFITM1 PTDSS2 PGGHG PSMD13 SIGIRR SIRT3 MIR6743 ANO9 ODF3 IFITM3 IFITM5
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	PTDSS2 B4GALNT4 SIGIRR ANO9 PKP3
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	B4GALNT4 SLC25A22 LMNTD2 RASSF7 SNORA52 MIR210 PKP3 CEND1 PNPLA2 POLR2L PTDSS2 RNH1 TSPAN4 HRAS PANO1 SIGIRR DRD4 PIDD1 TMEM80 MIR210HG LOC143666 PDDC1 LOC171391 PHRF1 EPS8L2 LOC101059906 SCT CRACR2B DEAF1 LRRC56 TALDO1 IRF7 ANO9 CDHR5 RPLP2 CHID1 CD151 AP2A2
nsv1070918	Chr.11:410499 - 414500 on Build GRCh38	Deletion	SIGIRR
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	LOC143666 B4GALNT4 LMNTD2 RASSF7 IFITM2 MIR210 PKP3 PHRF1 LOC101059906 IFITM1 PTDSS2 PGGHG RNH1 HRAS SIGIRR LRRC56 IRF7 ANO9 CDHR5 IFITM3 IFITM5 MIR210HG
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	MUC5B B4GALNT4 MIR6744 SLC25A22 LMNTD2 RASSF7 SNORA52 MUC5AC MIR210 TOLLIP PKP3 CEND1 PNPLA2 POLR2L PTDSS2 RNH1 MUC6 MUC2 TSPAN4 HRAS PANO1 SIGIRR DRD4 PIDD1 LOC101927503 TMEM80 MIR210HG LOC143666 PDDC1 LOC171391 PHRF1 EPS8L2 LOC101059906 SCT CRACR2B DEAF1 LRRC56 TALDO1 IRF7 ANO9 CDHR5 RPLP2 CHID1 CD151 AP2A2
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	B4GALNT4 SIGIRR ANO9 PKP3
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	SIGIRR ANO9
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	B4GALNT4 SIGIRR ANO9 PKP3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding