Hs03952362_cn

• Gene Symbol: CBFA2T3
• Assay Reference Genome Location: Chr.16:88880023 on build GRCh38
• Cytoband: 16q24.3

Target Gene Details

• Entrez Gene ID: 863
• Gene Name: CBFA2/RUNX1 translocation partner 3
• Gene Aliases: ETO2, MTG16, MTGR2, RUNX1T3, ZMYND4
• Location: Chr.16:88874855-88977198 on Build GRCh38
• Assay Gene Location: Within Intron 12

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CBFA2T3	NM_005187.5			NP_005178.4
	NM_175931.2			NP_787127.1
	XM_005256323.4			XP_005256380.1
	XM_011523419.2			XP_011521721.1
	AB010419.1			BAA29061.1
	AB010420.1			BAA29062.1
	AK090985.1
	AK097904.1
	AK314766.1
	BC047019.1
	BC062624.1			AAH62624.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv37n68	Chr.16:88767460 - 88944903 on Build GRCh38	Loss	CDT1 PABPN1L GALNS TRAPPC2L CBFA2T3 PIEZO1 LOC100129697 APRT LOC101927793 LOC107987238 LOC105371409
nsv1063024	Chr.16:88707330 - 89238482 on Build GRCh38	Gain	ACSF3 PABPN1L TRAPPC2L CBFA2T3 PIEZO1 LOC400558 APRT LOC101927793 MIR4722 ZNF778 LOC107987238 LOC105371409 LINC00304 CDT1 GALNS LOC100289580 LOC339059 CDH15 LOC100129697 CTU2 SLC22A31
nsv1928	Chr.16:88865211 - 88897277 on Build GRCh38	Insertion	PABPN1L CBFA2T3 LOC101927793
nsv471115	Chr.16:88801844 - 89197442 on Build GRCh38	Loss	ACSF3 PABPN1L TRAPPC2L CBFA2T3 LOC400558 APRT LOC101927793 LOC107987238 LOC105371409 LINC00304 CDT1 GALNS CDH15 LOC100129697 SLC22A31
nsv573674	Chr.16:88738775 - 89325907 on Build GRCh38	Gain	ACSF3 PABPN1L TRAPPC2L CBFA2T3 LOC105371414 PIEZO1 LOC400558 APRT LOC101927793 ZNF778 ANKRD11 LOC107987238 LOC105371409 LINC00304 CDT1 GALNS LOC100289580 LOC339059 CDH15 LOC100129697 SLC22A31 LOC100287036
esv3639555	Chr.16:88745961 - 88899576 on Build GRCh38	Gain	CDT1 PABPN1L GALNS TRAPPC2L CBFA2T3 PIEZO1 APRT LOC101927793 LOC107987238
nsv521217	Chr.16:88805821 - 89174375 on Build GRCh38	Loss	ACSF3 PABPN1L TRAPPC2L CBFA2T3 LOC400558 APRT LOC101927793 LOC107987238 LOC105371409 LINC00304 CDT1 GALNS CDH15 LOC100129697
nsv952071	Chr.16:88790893 - 89019992 on Build GRCh38	Deletion	CDT1 PABPN1L GALNS TRAPPC2L CBFA2T3 LOC100129697 APRT LOC101927793 LOC107987238 LOC105371409
nsv482951	Chr.16:88633593 - 90228345 on Build GRCh38	Loss	CBFA2T3 TCF25 MIR4722 MC1R SPATA2L VPS9D1 CDT1 IL17C FANCA LOC100289580 LOC339059 TUBB3 SNAI3-AS1 SLC22A31 GAS8-AS1 SPATA33 SPG7 ACSF3 CHMP1A RPL13 LOC400558 RNF166 ANKRD11 LOC107984817 TUBB8P7 GALNS CYBA PRDM7 LOC100129697 DBNDD1 LOC100287036 AFG3L1P PABPN1L MVD LOC105371414 PIEZO1 APRT DPEP1 URAHP LOC107987238 LOC105371409 VPS9D1-AS1 FAM157C LOC105371419 SNORD68 CDH15 ZNF276 LOC101927817 CENPBD1 DEF8 TRAPPC2L LOC101927793 ZNF778 LINC00304 CPNE7 SNAI3 SPIRE2 CTU2 CDK10 GAS8
esv3639561	Chr.16:88837996 - 88882065 on Build GRCh38	Gain	PABPN1L GALNS TRAPPC2L CBFA2T3
dgv3065n100	Chr.16:88711587 - 88927172 on Build GRCh38	Gain	PABPN1L TRAPPC2L CBFA2T3 PIEZO1 APRT LOC101927793 MIR4722 LOC107987238 CDT1 GALNS LOC100289580 LOC339059 CTU2

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transcription cofactor

Gene Ontology Categories:

Process(es)

response to hypoxia
transcription, DNA-templated
cell proliferation
negative regulation of cell proliferation
granulocyte differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
regulation of aerobic respiration

Function(s)

transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
metal ion binding