Hs04009874_cn

• Gene Symbol: IRF3
• Assay Reference Genome Location: Chr.19:49660176 on build GRCh38
• Cytoband: 19q13.33

Target Gene Details

• Entrez Gene ID: 3661
• Gene Name: interferon regulatory factor 3
• Gene Aliases: IIAE7
• Location: Chr.19:49659569-49665875 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IRF3	NM_001197122.1			NP_001184051.1
	NM_001197123.1			NP_001184052.1
	NM_001197124.1			NP_001184053.1
	NM_001197125.1			NP_001184054.1
	NM_001197126.1			NP_001184055.1
	NM_001197127.1			NP_001184056.1
	NM_001197128.1			NP_001184057.1
	NM_001571.5			NP_001562.1
	NR_045568.1
	XM_006723197.1			XP_006723260.1
	XM_006723198.1			XP_006723261.1
	XM_006723200.1			XP_006723263.1
	XM_006723201.1			XP_006723264.1
	XM_006723202.2			XP_006723265.1
	XM_017026766.1			XP_016882255.1
	XM_017026767.1			XP_016882256.1
	AA568913.1
	AB102886.1			BAD89415.1
	AB102887.1			BAD89416.1
	AK292027.1
	AK314421.1
	BC000660.2			AAH00660.1
	BC009395.2			AAH09395.1
	BC071721.1			AAH71721.1
	BM477213.1
	BU859806.1
	HM357932.1
	HM357933.1
	HM357934.1
	HM357935.1
	HM357936.1
	HM357937.1
	Z56281.1			CAA91227.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv469715	Chr.19:49572544 - 49730286 on Build GRCh38	Gain+Loss	IRF3 ADM5 PRMT1 SCAF1 MIR5088 NOSIP CPT1C PRR12 BCL2L12 RRAS PRRG2
nsv833865	Chr.19:49572545 - 49730286 on Build GRCh38	Gain+Loss	IRF3 ADM5 PRMT1 SCAF1 MIR5088 NOSIP CPT1C PRR12 BCL2L12 RRAS PRRG2
nsv9739	Chr.19:47901840 - 50143063 on Build GRCh38	Gain+Loss	KDELR1 SPHK2 CGB3 MIR4749 ATF5 DBP RCN3 VRK3 GRWD1 LMTK3 CGB7 SNORD32A CD37 FGF21 GFY ALDH16A1 SNAR-A14 DHDH SNORD35B SNAR-C4 FTL SCAF1 TMEM143 PPFIA3 FUT2 HSD17B14 NUCB1 PRRG2 PLEKHA4 TEAD2 RPL13A BCL2L12 SNAR-B1 PIH1D1 C19orf73 SNAR-G1 FAM83E CYTH2 LHB NOSIP CABP5 FUT1 GRIN2D PRR12 MIR6798 TSKS SLC6A16 SIGLEC16 IL4I1 PRMT1 MIR5088 SNAR-A12 SNAR-A2 SNAR-A9 SEC1P MIR6800 PLA2G4C-AS1 SNORD34 PNKP BAX RRAS NTN5 LIG1 SNORD33 SNAR-A3 SPACA4 RPL18 MED25 MIR6799 SLC17A7 FUZ ZNF473 SULT2B1 LOC105447645 PTOV1-AS1 SNAR-C3 CARD8 CA11 FLJ26850 IRF3 SNRNP70 SNAR-A6 CARD8-AS1 SNAR-A11 SNAR-C2 SNAR-C1 LOC101059948 SNAR-B2 PLA2G4C LIN7B LOC100287477 AP2A1 ZNF114 PTOV1-AS2 SNAR-A8 MIR150 ADM5 TBC1D17 LOC105372430 NUCB1-AS1 KCNA7 CPT1C SNAR-A10 TULP2 SNAR-A1 NTF4 AKT1S1 BCAT2 RUVBL2 MIR4751 CGB1 SIGLEC11 DKKL1 TRPM4 CCDC155 CCDC114 FCGRT LOC101928295 PPP1R15A SNAR-A5 SNORD35A PTH2 RPS11 NUP62 EMP3 BSPH1 CGB2 ELSPBP1 CGB5 FLT3LG IZUMO1 SYNGR4 MIR4750 SNAR-G2 SNAR-A4 RASIP1 HRC GYS1 C19orf68 KCNJ14 SNAR-D CGB8 PTOV1 SNAR-C5 SNAR-A7 MIR4324 SNAR-A13 MAMSTR
nsv817854	Chr.19:49618821 - 49726387 on Build GRCh38	Gain	IRF3 ADM5 PRMT1 SCAF1 MIR5088 CPT1C PRR12 BCL2L12 RRAS
nsv953600	Chr.19:49555044 - 49938043 on Build GRCh38	Deletion	IRF3 MIR4751 NOSIP PRR12 MIR4749 TSKS ATF5 NUP62 IL4I1 PRMT1 MIR5088 AP2A1 PTOV1-AS2 MIR6800 MIR4750 PNKP ADM5 SCAF1 TBC1D17 CPT1C RRAS PRRG2 PTOV1 MED25 MIR6799 AKT1S1 FUZ BCL2L12 PTOV1-AS1
nsv833864	Chr.19:49551790 - 49733819 on Build GRCh38	Gain	IRF3 ADM5 PRMT1 SCAF1 MIR5088 NOSIP CPT1C PRR12 BCL2L12 RRAS PRRG2
nsv1160655	Chr.19:49489110 - 49841830 on Build GRCh38	Deletion	IRF3 NOSIP FCGRT PRR12 SNORD35A TSKS RPS11 RCN3 SNORD32A PRMT1 MIR5088 AP2A1 SNORD35B MIR6800 SNORD34 MIR150 ADM5 SCAF1 CPT1C RRAS PRRG2 SNORD33 MED25 MIR6799 FUZ RPL13A BCL2L12 PTOV1-AS1
nsv828578	Chr.19:49560777 - 49680548 on Build GRCh38	Loss	IRF3 PRMT1 SCAF1 NOSIP PRR12 BCL2L12 RRAS PRRG2
nsv579908	Chr.19:49645135 - 49663393 on Build GRCh38	Loss	IRF3 SCAF1

More Information

Additional Information:

For this assay, SNP(s) [rs114450521] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

winged helix/forkhead transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
lipopolysaccharide-mediated signaling pathway
negative regulation of type I interferon production
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
TRIF-dependent toll-like receptor signaling pathway
MDA-5 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
type I interferon biosynthetic process
positive regulation of cytokine secretion
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
cellular response to dsRNA
macrophage apoptotic process
programmed necrotic cell death

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription cofactor activity
protein binding
identical protein binding
protein homodimerization activity