Hs04029932_cn

• Gene Symbol: APC2
• Assay Reference Genome Location: Chr.19:1453993 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10297
• Gene Name: APC2, WNT signaling pathway regulator
• Gene Aliases: APCL
• Location: Chr.19:1446268-1473244 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APC2	NM_005883.2			NP_005874.1
	XM_005259475.2			XP_005259532.1
	XM_006722607.2			XP_006722670.1
	XM_006722608.3			XP_006722671.2
	XM_006722609.3			XP_006722672.1
	XM_006722610.3			XP_006722673.2
	AB012162.1			BAA34611.1
	AF110334.1			AAD28183.1
	AF128222.1			AAF01784.1
	AJ012652.1			CAB61207.1
	AL078616.1
	BC032573.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv32942	Chr.19:1320268 - 1999205 on Build GRCh38	Gain+Loss	ONECUT3 MIR1909 ADAMTSL5 CSNK1G2-AS1 KLF16 DAZAP1 SCAMP4 NDUFS7 ATP8B3 REEP6 C19orf25 TCF3 BTBD2 REXO1 GAMT ABHD17A PCSK4 MBD3 CSNK1G2 MUM1 UQCR11 MEX3D ADAT3 APC2 PLK5 LOC100288123 RPS15
nsv578279	Chr.19:1413575 - 1530061 on Build GRCh38	Gain	APC2 PCSK4 PLK5 ADAMTSL5 REEP6 C19orf25 DAZAP1 RPS15
nsv833705	Chr.19:1380125 - 1544934 on Build GRCh38	Loss	APC2 PCSK4 NDUFS7 PLK5 ADAMTSL5 REEP6 C19orf25 GAMT DAZAP1 RPS15
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	GPX4 POLR2E CNN2 ARID3A CIRBP-AS1 SBNO2 ADAMTSL5 ARHGAP45 DAZAP1 EFNA2 WDR18 NDUFS7 CIRBP ATP5D REEP6 STK11 C19orf25 CBARP GAMT PCSK4 C19orf24 MUM1 LOC102725180 APC2 TMEM259 MIDN PLK5 RNU6-2 ABCA7 GRIN3B LOC105372235 RPS15
nsv953942	Chr.19:1371602 - 2057401 on Build GRCh38	Deletion	ONECUT3 MIR1909 ADAMTSL5 CSNK1G2-AS1 KLF16 DAZAP1 SCAMP4 NDUFS7 ATP8B3 REEP6 C19orf25 TCF3 BTBD2 REXO1 GAMT ABHD17A PCSK4 MBD3 CSNK1G2 MUM1 UQCR11 MEX3D ADAT3 APC2 PLK5 MKNK2 LOC100288123 RPS15
nsv817811	Chr.19:1444420 - 1475392 on Build GRCh38	Loss	APC2 C19orf25

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cell fate specification
negative regulation of microtubule depolymerization
pattern specification process
cell proliferation
Wnt signaling pathway
cell migration
negative regulation of catenin import into nucleus
regulation of cell differentiation
positive regulation of protein catabolic process
negative regulation of canonical Wnt signaling pathway

Function(s)

protein binding
beta-catenin binding
microtubule binding
gamma-catenin binding