Hs04366415_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136892068 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 MIR4479 MIR4292 PHPT1 C9orf172 FBXW5 MAMDC4 RABL6 EDF1
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	CCDC183-AS1 C8G MIR6722 RABL6 EDF1 TRAF2 C9orf142 MIR4292 LCN6 PTGDS MAMDC4 PRR31 LCN15 MIR4479 PHPT1 LCN10 C9orf172 FBXW5 CCDC183 LOC100128593 ABCA2 CLIC3 LCN12 LCNL1 LCN8 TMEM141
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	ENTPD2 NSMF NELFB LOC101930307 C8G C9orf139 EXD3 MIR4292 LRRC26 MAN1B1 MAMDC4 SLC34A3 SAPCD2 PHPT1 C9orf172 DPP7 CCDC183 FUT7 CLIC3 SSNA1 TMEM210 LCN12 NDOR1 NRARP PNPLA7 LCNL1 MAN1B1-AS1 TUBB4B UAP1L1 RNF208 C9orf173-AS1 RNF224 CCDC183-AS1 RABL6 TPRN STPG3 TMEM203 EDF1 TRAF2 C9orf142 ENTPD8 PTGDS MIR3621 NOXA1 FAM166A PRR31 TOR4A MIR4479 ANAPC2 NPDC1 FBXW5 CYSRT1 ABCA2 MIR7114 GRIN1
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	SNAPC4 CCDC183-AS1 HSPC324 C9orf163 MIR6722 EGFL7 RABL6 MIR4673 NALT1 EDF1 TRAF2 AGPAT2 GPSM1 DNLZ SEC16A MIR4292 MIR4674 LCN6 MAMDC4 LCN15 MIR4479 SNORA17A SDCCAG3 MIR126 PHPT1 LCN10 INPP5E C9orf172 NOTCH1 CCDC183 LINC01451 SNORA17B LOC100128593 PMPCA CARD9 SNHG7 LCN8 FAM69B TMEM141
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	ENTPD2 HSPC324 LOC101930307 C9orf163 C8G MIR6722 C9orf139 NALT1 AGPAT2 DNLZ MIR4292 LRRC26 MAN1B1 MAMDC4 LCN15 SNORA17A SDCCAG3 MIR126 SAPCD2 PHPT1 C9orf172 DPP7 NOTCH1 CCDC183 FUT7 CLIC3 PMPCA CARD9 TMEM210 LCN12 LCNL1 LCN8 FAM69B MAN1B1-AS1 UAP1L1 SNAPC4 CCDC183-AS1 EGFL7 RABL6 MIR4673 EDF1 TRAF2 C9orf142 SEC16A MIR4674 LCN6 PTGDS MIR3621 PRR31 MIR4479 LCN10 INPP5E NPDC1 FBXW5 LINC01451 SNORA17B LOC100128593 ABCA2 SNHG7 GRIN1 TMEM141
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	ENTPD2 NELFB HSPC324 LOC101930307 C8G MIR6722 C9orf139 AGPAT2 EXD3 MIR4292 LRRC26 MAN1B1 MAMDC4 LCN15 SLC34A3 SNORA17A MIR126 SAPCD2 PHPT1 C9orf172 DPP7 CCDC183 FUT7 CLIC3 SSNA1 TMEM210 LCN12 NDOR1 NRARP LCNL1 LCN8 FAM69B MAN1B1-AS1 TUBB4B UAP1L1 RNF208 C9orf173-AS1 RNF224 CCDC183-AS1 EGFL7 RABL6 TPRN STPG3 TMEM203 EDF1 TRAF2 C9orf142 LCN6 PTGDS MIR3621 FAM166A PRR31 TOR4A MIR4479 LCN10 ANAPC2 NPDC1 FBXW5 LINC01451 SNORA17B LOC100128593 CYSRT1 ABCA2 SNHG7 GRIN1 TMEM141

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding