Hs04366415_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136892068 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	NM_021138.3			NP_066961.2
	XM_011518973.2			XP_011517275.1
	XM_011518974.2			XP_011517276.1
	XM_011518975.2			XP_011517277.1
	XM_011518976.2			XP_011517278.1
	XM_011518977.2			XP_011517279.1
	AK054686.1			BAB70792.1
	AK222961.1
	AK289722.1
	AK294607.1
	AK298370.1
	BC033810.1			AAH33810.1
	BC043492.1			AAH43492.1
	BM785733.1
	BX538160.1			CAD98040.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	FBXW5 MAMDC4 RABL6 EDF1 MIR4292 C9orf172 PHPT1 MIR4479 TRAF2
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	FBXW5 RABL6 LCNL1 TRAF2 LCN6 ABCA2 MAMDC4 LCN12 PTGDS MIR6722 C9orf172 PHPT1 CCDC183-AS1 CCDC183 C9orf142 TMEM141 PRR31 LOC100128593 EDF1 LCN8 MIR4479 LCN10 MIR4292 CLIC3 C8G LCN15
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	NRARP FBXW5 RABL6 TRAF2 ENTPD2 MAMDC4 NSMF PTGDS C9orf172 EXD3 PHPT1 CCDC183-AS1 TMEM210 PRR31 C9orf139 EDF1 PNPLA7 STPG3 NDOR1 LOC101930307 TPRN LRRC26 MIR4292 C8G TOR4A ANAPC2 C9orf173-AS1 MAN1B1 MIR7114 SLC34A3 SSNA1 RNF208 LCNL1 MIR3621 CYSRT1 TMEM203 NPDC1 MAN1B1-AS1 DPP7 UAP1L1 SAPCD2 FAM166A ABCA2 RNF224 LCN12 NOXA1 TUBB4B CCDC183 C9orf142 NELFB MIR4479 ENTPD8 FUT7 GRIN1 CLIC3
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	FBXW5 SNAPC4 PMPCA RABL6 SNORA17B EGFL7 TRAF2 ENTPD2 MAMDC4 PTGDS MIR6722 C9orf172 PHPT1 CCDC183-AS1 FAM69B TMEM141 TMEM210 SDCCAG3 PRR31 AGPAT2 C9orf139 EDF1 LCN8 MIR4674 LCN10 LOC101930307 CARD9 LRRC26 NOTCH1 MIR4292 C8G LCN15 MAN1B1 HSPC324 NALT1 LCNL1 MIR3621 MIR126 MIR4673 SNORA17A NPDC1 MAN1B1-AS1 DNLZ DPP7 UAP1L1 SAPCD2 LCN6 ABCA2 C9orf163 LCN12 CCDC183 C9orf142 SNHG7 LOC100128593 SEC16A LINC01451 MIR4479 FUT7 INPP5E GRIN1 CLIC3
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	HSPC324 SNAPC4 PMPCA RABL6 NALT1 MIR126 MIR4673 SNORA17B SNORA17A EGFL7 DNLZ TRAF2 LCN6 MAMDC4 C9orf163 MIR6722 C9orf172 PHPT1 CCDC183-AS1 CCDC183 FAM69B TMEM141 SDCCAG3 SNHG7 AGPAT2 LOC100128593 SEC16A EDF1 LINC01451 LCN8 MIR4479 MIR4674 LCN10 GPSM1 CARD9 NOTCH1 INPP5E MIR4292 LCN15
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	NRARP FBXW5 RABL6 SNORA17B EGFL7 TRAF2 ENTPD2 MAMDC4 PTGDS MIR6722 C9orf172 EXD3 PHPT1 CCDC183-AS1 FAM69B TMEM141 TMEM210 PRR31 AGPAT2 C9orf139 EDF1 LCN8 LCN10 STPG3 NDOR1 LOC101930307 TPRN LRRC26 MIR4292 C8G LCN15 TOR4A ANAPC2 C9orf173-AS1 MAN1B1 HSPC324 SLC34A3 SSNA1 RNF208 LCNL1 MIR3621 MIR126 CYSRT1 TMEM203 SNORA17A NPDC1 MAN1B1-AS1 DPP7 UAP1L1 SAPCD2 FAM166A LCN6 ABCA2 RNF224 LCN12 TUBB4B CCDC183 C9orf142 NELFB SNHG7 LOC100128593 LINC01451 MIR4479 FUT7 GRIN1 CLIC3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding