Hs04371532_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136885224 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	TRAF2 FBXW5 PHPT1 EDF1 MAMDC4 C9orf172 MIR4479 MIR4292 RABL6
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LCN15 C8G MAMDC4 MIR4292 PTGDS RABL6 LCN8 LCN6 PRR31 MIR4479 ABCA2 CLIC3 TRAF2 FBXW5 C9orf142 CCDC183-AS1 LOC100128593 LCNL1 MIR6722 LCN12 LCN10 PHPT1 EDF1 C9orf172 TMEM141 CCDC183
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	MAN1B1 DPP7 C8G MIR4292 TOR4A RNF224 RABL6 TMEM210 SLC34A3 GRIN1 FUT7 SAPCD2 TRAF2 FBXW5 MIR3621 C9orf142 CYSRT1 LRRC26 TMEM203 LCN12 NRARP ANAPC2 NELFB C9orf172 CCDC183 NDOR1 MIR7114 SSNA1 MAMDC4 PTGDS PNPLA7 FAM166A NPDC1 PRR31 EXD3 MIR4479 ABCA2 RNF208 CLIC3 ENTPD8 CCDC183-AS1 MAN1B1-AS1 LCNL1 C9orf173-AS1 NSMF UAP1L1 ENTPD2 PHPT1 EDF1 TUBB4B LOC101930307 STPG3 C9orf139 NOXA1 TPRN
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	MAN1B1 MIR4673 DPP7 C8G MIR4292 RABL6 PMPCA SNHG7 LCN8 TMEM210 SDCCAG3 GRIN1 FUT7 SAPCD2 TRAF2 FBXW5 MIR3621 C9orf142 SNAPC4 MIR6722 LRRC26 LCN12 NALT1 C9orf172 LINC01451 NOTCH1 CCDC183 LCN15 MAMDC4 AGPAT2 FAM69B CARD9 PTGDS MIR4674 LCN6 C9orf163 NPDC1 EGFL7 PRR31 MIR4479 ABCA2 SEC16A CLIC3 HSPC324 CCDC183-AS1 MIR126 SNORA17A LOC100128593 DNLZ MAN1B1-AS1 LCNL1 UAP1L1 ENTPD2 LCN10 PHPT1 EDF1 LOC101930307 SNORA17B TMEM141 C9orf139 INPP5E
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	LCN15 MIR4673 GPSM1 MAMDC4 AGPAT2 MIR4292 FAM69B CARD9 MIR4674 RABL6 PMPCA SNHG7 LCN8 LCN6 C9orf163 EGFL7 MIR4479 SDCCAG3 SEC16A TRAF2 HSPC324 CCDC183-AS1 SNAPC4 MIR126 SNORA17A LOC100128593 DNLZ MIR6722 LCN10 NALT1 PHPT1 EDF1 SNORA17B C9orf172 TMEM141 LINC01451 NOTCH1 CCDC183 INPP5E
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	MAN1B1 DPP7 C8G MIR4292 TOR4A RNF224 RABL6 SNHG7 LCN8 TMEM210 SLC34A3 GRIN1 FUT7 SAPCD2 TRAF2 FBXW5 MIR3621 C9orf142 CYSRT1 MIR6722 LRRC26 TMEM203 LCN12 NRARP ANAPC2 NELFB C9orf172 LINC01451 CCDC183 NDOR1 LCN15 SSNA1 MAMDC4 AGPAT2 FAM69B PTGDS FAM166A LCN6 NPDC1 EGFL7 PRR31 EXD3 MIR4479 ABCA2 RNF208 CLIC3 HSPC324 CCDC183-AS1 MIR126 SNORA17A LOC100128593 MAN1B1-AS1 LCNL1 C9orf173-AS1 UAP1L1 ENTPD2 LCN10 PHPT1 EDF1 TUBB4B LOC101930307 SNORA17B STPG3 TMEM141 C9orf139 TPRN

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding