Hs04371532_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136885224 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	EDF1 C9orf172 MIR4292 RABL6 MIR4479 MAMDC4 TRAF2 PHPT1 FBXW5
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	C9orf172 MIR4292 MIR6722 LCN10 LCNL1 LCN8 ABCA2 LCN6 RABL6 CCDC183-AS1 MAMDC4 PRR31 CCDC183 CLIC3 FBXW5 EDF1 LCN12 PTGDS C8G LCN15 TRAF2 TMEM141 MIR4479 C9orf142 PHPT1 LOC100128593
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	C9orf172 SLC34A3 MIR4292 FUT7 NRARP LCNL1 MAN1B1 NDOR1 RABL6 CCDC183-AS1 PRR31 TMEM210 CCDC183 C9orf139 GRIN1 FBXW5 ANAPC2 EDF1 LCN12 PTGDS LRRC26 DPP7 C8G EXD3 CYSRT1 RNF208 LOC101930307 SSNA1 STPG3 NPDC1 PNPLA7 SAPCD2 ENTPD8 MAN1B1-AS1 MIR7114 C9orf142 PHPT1 TPRN NSMF C9orf173-AS1 FAM166A TMEM203 MIR3621 ABCA2 TUBB4B MAMDC4 CLIC3 NELFB TRAF2 TOR4A ENTPD2 MIR4479 UAP1L1 NOXA1 RNF224
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	C9orf172 MIR4292 MIR6722 LCN10 MIR126 SEC16A SDCCAG3 LCN8 SNAPC4 GPSM1 LINC01451 LCN6 MIR4674 RABL6 HSPC324 PMPCA CCDC183-AS1 MAMDC4 AGPAT2 CCDC183 SNORA17A EDF1 LCN15 INPP5E TRAF2 CARD9 FAM69B C9orf163 SNORA17B DNLZ TMEM141 NALT1 EGFL7 MIR4479 NOTCH1 MIR4673 PHPT1 LOC100128593 SNHG7
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	C9orf172 MIR4292 FUT7 LCNL1 MAN1B1 SEC16A LINC01451 RABL6 HSPC324 CCDC183-AS1 PRR31 TMEM210 CCDC183 C9orf139 GRIN1 FBXW5 SNORA17A EDF1 LCN12 PTGDS LRRC26 DPP7 C8G LCN15 INPP5E SNORA17B DNLZ LOC101930307 NPDC1 SAPCD2 NALT1 MAN1B1-AS1 EGFL7 NOTCH1 C9orf142 MIR4673 PHPT1 SNHG7 MIR6722 LCN10 MIR126 MIR3621 SDCCAG3 LCN8 SNAPC4 ABCA2 LCN6 MIR4674 PMPCA MAMDC4 AGPAT2 CLIC3 TRAF2 CARD9 FAM69B ENTPD2 C9orf163 TMEM141 MIR4479 UAP1L1 LOC100128593
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	C9orf172 SLC34A3 MIR4292 FUT7 NRARP LCNL1 MAN1B1 NDOR1 LINC01451 RABL6 HSPC324 CCDC183-AS1 PRR31 TMEM210 CCDC183 C9orf139 GRIN1 FBXW5 ANAPC2 SNORA17A EDF1 LCN12 PTGDS LRRC26 DPP7 C8G EXD3 LCN15 CYSRT1 SNORA17B RNF208 LOC101930307 SSNA1 STPG3 NPDC1 SAPCD2 MAN1B1-AS1 EGFL7 C9orf142 PHPT1 TPRN C9orf173-AS1 FAM166A SNHG7 MIR6722 LCN10 MIR126 TMEM203 MIR3621 LCN8 ABCA2 LCN6 TUBB4B MAMDC4 AGPAT2 CLIC3 NELFB TRAF2 TOR4A FAM69B ENTPD2 TMEM141 MIR4479 UAP1L1 LOC100128593 RNF224

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding