Hs04402045_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:414791 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_001135054.1			NP_001128526.1
	NM_021805.2			NP_068577.2
	XM_005253044.2			XP_005253101.1
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	XM_005253048.4			XP_005253105.1
	XM_017018099.1			XP_016873588.1
	XM_017018100.1			XP_016873589.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	BC106007.1			AAI06008.1
	DA963481.1
	DB112269.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	HRAS LMNTD2 CDHR5 LOC101059906 IRF7 RNH1 PHRF1 LOC143666 B4GALNT4 IFITM1 ANO9 MIR210 SIGIRR PTDSS2 RASSF7 IFITM5 IFITM2 LRRC56 MIR210HG IFITM3 PGGHG PKP3
nsv467633	Chr.11:366710 - 432436 on Build GRCh38	Loss	SIGIRR B4GALNT4 PKP3 ANO9
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	MUC5AC LOC101059906 SNORA52 IRF7 MIR6744 PHRF1 LOC143666 CD151 PDDC1 CEND1 MUC6 SCT CHID1 MUC2 SIGIRR SLC25A22 RASSF7 PIDD1 LRRC56 DEAF1 RPLP2 MUC5B POLR2L TMEM80 PNPLA2 HRAS LMNTD2 CDHR5 CRACR2B TALDO1 RNH1 B4GALNT4 LOC171391 ANO9 MIR210 PANO1 PTDSS2 LOC101927503 MIR210HG TSPAN4 EPS8L2 AP2A2 DRD4 PKP3 TOLLIP
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	SIGIRR ANO9
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	SIGIRR ANO9
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	MUC5AC LOC101059906 SNORA52 IRF7 MIR6744 PHRF1 LOC143666 CD151 PDDC1 CEND1 MUC6 SCT TOLLIP-AS1 CHID1 MUC2 SIGIRR SLC25A22 RASSF7 PIDD1 LRRC56 DEAF1 RPLP2 MUC5B POLR2L TMEM80 PNPLA2 HRAS LMNTD2 CDHR5 CRACR2B TALDO1 RNH1 LOC171391 ANO9 MIR210 PANO1 PTDSS2 LOC101927503 MIR210HG TSPAN4 EPS8L2 AP2A2 DRD4 TOLLIP
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	SIGIRR ANO9
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	SIGIRR B4GALNT4 PKP3 ANO9
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	SIGIRR PTDSS2 RNH1 B4GALNT4 PKP3 ANO9
dgv1012n100	Chr.11:198510 - 427836 on Build GRCh38	Gain	ODF3 MIR6743 B4GALNT4 PSMD13 IFITM1 ANO9 SIRT3 RIC8A BET1L SIGIRR IFITM5 IFITM2 IFITM3 PGGHG PKP3 NLRP6
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	SIGIRR PTDSS2 B4GALNT4 PKP3 ANO9
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	LOC101059906 SNORA52 IRF7 PHRF1 LOC143666 CD151 PDDC1 CEND1 SCT CHID1 SIGIRR SLC25A22 RASSF7 PIDD1 LRRC56 DEAF1 RPLP2 POLR2L TMEM80 PNPLA2 HRAS LMNTD2 CDHR5 CRACR2B TALDO1 RNH1 B4GALNT4 LOC171391 ANO9 MIR210 PANO1 PTDSS2 MIR210HG TSPAN4 EPS8L2 AP2A2 DRD4 PKP3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding