Hs04402045_cn

• Gene Symbol: SIGIRR
• Assay Reference Genome Location: Chr.11:414791 on build GRCh38
• Cytoband: 11p15.5

Target Gene Details

• Entrez Gene ID: 59307
• Gene Name: single Ig and TIR domain containing
• Gene Aliases: IL-1R8, TIR8
• Location: Chr.11:405716-417454 on Build GRCh38
• Assay Gene Location: Overlaps Intron 2 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SIGIRR	NM_001135053.1			NP_001128525.1
	NM_001135054.1			NP_001128526.1
	NM_021805.2			NP_068577.2
	XM_005253044.2			XP_005253101.1
	XM_005253045.1			XP_005253102.1
	XM_005253046.1			XP_005253103.1
	XM_005253048.4			XP_005253105.1
	XM_017018099.1			XP_016873588.1
	XM_017018100.1			XP_016873589.1
	AK025099.1			BAB15066.1
	AK093427.1
	AK172830.1			BAD18795.1
	BC025953.1			AAH25953.1
	BC106007.1			AAI06008.1
	DA963481.1
	DB112269.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv527327	Chr.11:295343 - 620599 on Build GRCh38	Loss	IFITM2 LRRC56 ANO9 IFITM1 CDHR5 B4GALNT4 SIGIRR PTDSS2 LOC143666 PKP3 IFITM5 MIR210 IFITM3 HRAS RNH1 RASSF7 IRF7 LMNTD2 MIR210HG LOC101059906 PGGHG PHRF1
nsv469923	Chr.11:378188 - 1302334 on Build GRCh38	Loss	EPS8L2 ANO9 CDHR5 DRD4 CRACR2B B4GALNT4 PTDSS2 CD151 POLR2L TSPAN4 MIR210 HRAS RASSF7 MIR6744 TOLLIP CHID1 LMNTD2 PIDD1 LOC101927503 TMEM80 LOC101059906 LRRC56 PNPLA2 PDDC1 LOC171391 AP2A2 RPLP2 MUC6 TALDO1 SIGIRR MUC5AC MUC5B LOC143666 PKP3 DEAF1 SCT RNH1 SNORA52 SLC25A22 IRF7 PANO1 MUC2 MIR210HG CEND1 PHRF1
nsv552776	Chr.11:366710 - 432436 on Build GRCh38	Loss	ANO9 B4GALNT4 SIGIRR PKP3
nsv552826	Chr.11:412626 - 431606 on Build GRCh38	Gain	ANO9 SIGIRR
nsv552825	Chr.11:412505 - 431554 on Build GRCh38	Gain+Loss	ANO9 SIGIRR
esv2759794	Chr.11:409846 - 1336162 on Build GRCh38	Loss	EPS8L2 ANO9 CDHR5 DRD4 CRACR2B PTDSS2 CD151 TOLLIP-AS1 POLR2L TSPAN4 MIR210 HRAS RASSF7 MIR6744 TOLLIP CHID1 LMNTD2 PIDD1 LOC101927503 TMEM80 LOC101059906 LRRC56 PNPLA2 PDDC1 LOC171391 AP2A2 RPLP2 MUC6 TALDO1 SIGIRR MUC5AC MUC5B LOC143666 DEAF1 SCT RNH1 SNORA52 SLC25A22 IRF7 PANO1 MUC2 MIR210HG CEND1 PHRF1
esv3891907	Chr.11:409815 - 424291 on Build GRCh38	Loss	ANO9 SIGIRR
nsv951268	Chr.11:368601 - 503700 on Build GRCh38	Deletion	ANO9 RNH1 B4GALNT4 SIGIRR PTDSS2 PKP3
nsv552770	Chr.11:356090 - 444628 on Build GRCh38	Gain	ANO9 B4GALNT4 SIGIRR PKP3
dgv1505n54	Chr.11:198510 - 470331 on Build GRCh38	Gain	IFITM2 ANO9 IFITM1 ODF3 B4GALNT4 SIGIRR PTDSS2 PKP3 IFITM5 MIR6743 IFITM3 RIC8A PSMD13 NLRP6 SIRT3 BET1L PGGHG
nsv1159790	Chr.11:340219 - 491334 on Build GRCh38	Deletion	ANO9 B4GALNT4 SIGIRR PTDSS2 PKP3
dgv182e199	Chr.11:349830 - 943372 on Build GRCh38	Deletion	EPS8L2 ANO9 CDHR5 DRD4 CRACR2B B4GALNT4 PTDSS2 CD151 POLR2L TSPAN4 MIR210 HRAS RASSF7 CHID1 LMNTD2 PIDD1 TMEM80 LOC101059906 LRRC56 PNPLA2 PDDC1 LOC171391 AP2A2 RPLP2 TALDO1 SIGIRR LOC143666 PKP3 DEAF1 SCT RNH1 SNORA52 SLC25A22 IRF7 PANO1 MIR210HG CEND1 PHRF1

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

negative regulation of cytokine-mediated signaling pathway
acute-phase response
signal transduction
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of chemokine biosynthetic process

Function(s)

protein binding