Hs04595384_cn

• Gene Symbol: KYNU
• Assay Reference Genome Location: Chr.2:142891675 on build GRCh38
• Cytoband: 2q22.2

Target Gene Details

• Entrez Gene ID: 8942
• Gene Name: kynureninase
• Gene Aliases: KYNUU
• Location: Chr.2:142877626-143042316 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
KYNU	NM_001032998.1			NP_001028170.1
	NM_001199241.1			NP_001186170.1
	NM_003937.2			NP_003928.1
	XM_017005217.1			XP_016860706.1
	AK223426.1			BAD97146.1
	AK290900.1
	AK292095.1
	AK315343.1
	AL548658.3
	BC000879.1			AAH00879.1
	CB151988.1
	CR457423.1			CAG33704.1
	U57721.1			AAC50650.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834395	Chr.2:142777629 - 142971815 on Build GRCh38	Gain	KYNU

More Information

Additional Information:

For this assay, SNP(s) [rs76560560] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

hydrolase

Gene Ontology Categories:

Process(es)

tryptophan catabolic process
tryptophan catabolic process to kynurenine
tryptophan catabolic process to acetyl-CoA
quinolinate biosynthetic process
response to interferon-gamma
'de novo' NAD biosynthetic process from tryptophan
response to vitamin B6
anthranilate metabolic process
L-kynurenine catabolic process

Function(s)

pyridoxal phosphate binding
kynureninase activity
protein homodimerization activity