Hs04974661_cn

• Gene Symbol: EPHB4
• Assay Reference Genome Location: Chr.7:100804033 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 2050
• Gene Name: EPH receptor B4
• Gene Aliases: HTK, MYK1, TYRO11
• Location: Chr.7:100802565-100827521 on Build GRCh38
• Assay Gene Location: Within Intron 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EPHB4	NM_004444.4			NP_004435.3
	XM_017011816.1			XP_016867305.1
	AB209644.1			BAD92881.1
	AK301224.1
	AY056048.1			AAL14195.1
	BC004264.1			AAH04264.1
	BC052804.1			AAH52804.1
	U07695.1			AAA20598.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470381	Chr.7:100642568 - 100834358 on Build GRCh38	Loss	GNB2 EPHB4 ACTL6B LOC105375429 POP7 GIGYF1 EPO TFR2 ZAN
esv2759547	Chr.7:100757867 - 101105965 on Build GRCh38	Gain+Loss	ACHE SLC12A9 TRIP6 MIR6875 UFSP1 TRIM56 EPHB4 MUC12 MUC17 LOC102724094 ZAN SRRT MUC3A
esv2734888	Chr.7:99975623 - 101290285 on Build GRCh38	Deletion	PILRA MBLAC1 C7orf43 TFR2 MIR93 TRIP6 MCM7 ZNHIT1 ZKSCAN1 STAG3L5P SERPINE1 TRIM56 EPHB4 MIR4653 LRCH4 COPS6 PCOLCE-AS1 MIR6840 LOC102724094 PILRB SPDYE3 AZGP1 ZCWPW1 CNPY4 STAG3L5P-PVRIG2P-PILRB MOGAT3 GPC2 POP7 GIGYF1 SRRT TSC22D4 MIR106B PLOD3 ACHE PVRIG2P LOC105375429 NAT16 EPO MIR25 STAG3 ACTL6B FIS1 MOSPD3 GATS MUC12 MEPCE SAP25 ZASP MUC17 ZAN ZSCAN21 AP4M1 MUC3A PVRIG AP1S1 PPP1R35 CLDN15 ZNF3 MIR4658 GNB2 TAF6 VGF SLC12A9 AGFG2 LAMTOR4 MIR6875 UFSP1 PCOLCE PMS2P1 GAL3ST4 C7orf61 AZGP1P1 NYAP1 FBXO24
nsv607965	Chr.7:100776465 - 100899511 on Build GRCh38	Loss	ACHE EPHB4 SLC12A9 TRIP6 ZAN SRRT MIR6875 UFSP1
nsv1020837	Chr.7:100715499 - 100911015 on Build GRCh38	Loss	ACHE EPHB4 EPO SLC12A9 TRIP6 ZAN SRRT MIR6875 UFSP1
nsv951388	Chr.7:100741378 - 100838178 on Build GRCh38	Deletion	EPHB4 ZAN

More Information

Additional Information:

For this assay, SNP(s) [rs77093870] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

angiogenesis
cell migration involved in sprouting angiogenesis
heart morphogenesis
cell adhesion
peptidyl-tyrosine phosphorylation
protein autophosphorylation
ephrin receptor signaling pathway

Function(s)

transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding