Hs04974661_cn

• Gene Symbol: EPHB4
• Assay Reference Genome Location: Chr.7:100804033 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 2050
• Gene Name: EPH receptor B4
• Gene Aliases: HTK, MYK1, TYRO11
• Location: Chr.7:100802565-100827521 on Build GRCh38
• Assay Gene Location: Within Intron 16

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EPHB4	NM_004444.4			NP_004435.3
	XM_017011816.1			XP_016867305.1
	AB209644.1			BAD92881.1
	AK301224.1
	AY056048.1			AAL14195.1
	BC004264.1			AAH04264.1
	BC052804.1			AAH52804.1
	U07695.1			AAA20598.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759547	Chr.7:100757867 - 101105965 on Build GRCh38	Gain+Loss	MIR6875 MUC3A MUC12 SLC12A9 EPHB4 UFSP1 MUC17 LOC102724094 ACHE SRRT TRIP6 TRIM56 ZAN
nsv470381	Chr.7:100642568 - 100834358 on Build GRCh38	Loss	GIGYF1 GNB2 TFR2 EPHB4 LOC105375429 EPO ACTL6B ZAN POP7
esv2734888	Chr.7:99975623 - 101290285 on Build GRCh38	Deletion	MIR4658 GNB2 NYAP1 CLDN15 EPO ACTL6B SPDYE3 LOC102724094 MIR106B ACHE MIR25 FBXO24 FIS1 CNPY4 TAF6 TRIM56 PILRA ZAN POP7 ZNF3 GIGYF1 AGFG2 SLC12A9 MOGAT3 LAMTOR4 LOC105375429 MIR6840 TSC22D4 SAP25 UFSP1 MBLAC1 SERPINE1 C7orf61 ZCWPW1 AP1S1 GAL3ST4 STAG3 MIR93 PILRB ZKSCAN1 MIR6875 GPC2 NAT16 PVRIG PVRIG2P STAG3L5P ZNHIT1 TFR2 MOSPD3 MUC17 PCOLCE-AS1 MEPCE SRRT MCM7 STAG3L5P-PVRIG2P-PILRB PPP1R35 COPS6 AZGP1 PMS2P1 PLOD3 C7orf43 AP4M1 MUC3A MUC12 ZASP VGF AZGP1P1 EPHB4 LRCH4 MIR4653 GATS TRIP6 PCOLCE ZSCAN21
nsv607965	Chr.7:100776465 - 100899511 on Build GRCh38	Loss	ACHE MIR6875 SRRT SLC12A9 TRIP6 EPHB4 UFSP1 ZAN
nsv1020837	Chr.7:100715499 - 100911015 on Build GRCh38	Loss	ACHE MIR6875 SRRT SLC12A9 TRIP6 EPHB4 EPO UFSP1 ZAN
nsv951388	Chr.7:100741378 - 100838178 on Build GRCh38	Deletion	EPHB4 ZAN

More Information

Additional Information:

For this assay, SNP(s) [rs77093870] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

angiogenesis
cell migration involved in sprouting angiogenesis
heart morphogenesis
cell adhesion
peptidyl-tyrosine phosphorylation
protein autophosphorylation
ephrin receptor signaling pathway

Function(s)

transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding