Hs05057450_cn

• Gene Symbol: AGO2
• Assay Reference Genome Location: Chr.8:140520208 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 27161
• Gene Name: argonaute 2, RISC catalytic component
• Gene Aliases: EIF2C2, Q10
• Location: Chr.8:140520158-140642406 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
AGO2	XM_011516965.2			XP_011515267.1
	XM_011516966.2			XP_011515268.1
	XM_011516968.2			XP_011515270.2
	XM_017013317.1			XP_016868806.1
	AK096164.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2737756	Chr.8:140419230 - 141917755 on Build GRCh38	Deletion	CHRAC1 PTP4A3 LOC107986982 LOC105375787 MIR1302-7 MROH5 FP248 GPR20 SLC45A4 PTK2 AGO2 DENND3 LINC01300 MIR151A TRAPPC9
nsv1016282	Chr.8:140453461 - 140537127 on Build GRCh38	Gain	CHRAC1 AGO2 TRAPPC9
nsv509283	Chr.8:140435015 - 140522401 on Build GRCh38	Insertion	CHRAC1 AGO2 TRAPPC9
nsv1126125	Chr.8:140419236 - 141917668 on Build GRCh38	Deletion	CHRAC1 PTP4A3 LOC107986982 LOC105375787 MIR1302-7 MROH5 FP248 GPR20 SLC45A4 PTK2 AGO2 DENND3 LINC01300 MIR151A TRAPPC9
dgv12367n54	Chr.8:140431882 - 140524741 on Build GRCh38	Gain	CHRAC1 AGO2 TRAPPC9

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

translation initiation factor

Gene Ontology Categories:

Process(es)

transcription, DNA-templated
translation
translational initiation
Wnt signaling pathway, calcium modulating pathway
post-embryonic development
RNA secondary structure unwinding
miRNA metabolic process
gene silencing by RNA
pre-miRNA processing
siRNA loading onto RISC involved in RNA interference
posttranscriptional gene silencing by RNA
production of miRNAs involved in gene silencing by miRNA
miRNA mediated inhibition of translation
mRNA cleavage involved in gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
phosphatidylinositol-mediated signaling
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
RNA phosphodiester bond hydrolysis, endonucleolytic
mRNA cleavage involved in gene silencing by siRNA
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Function(s)

RNA 7-methylguanosine cap binding
RNA polymerase II core binding
core promoter binding
double-stranded RNA binding
single-stranded RNA binding
mRNA binding
translation initiation factor activity
endoribonuclease activity
protein binding
protein C-terminus binding
siRNA binding
miRNA binding
poly(A) RNA binding
metal ion binding
endoribonuclease activity, cleaving siRNA-paired mRNA
endoribonuclease activity, cleaving miRNA-paired mRNA