Hs05095768_cn

• Gene Symbol: MGMT
• Assay Reference Genome Location: Chr.10:129473744 on build GRCh38
• Cytoband: 10q26.3

Target Gene Details

• Entrez Gene ID: 4255
• Gene Name: O-6-methylguanine-DNA methyltransferase
• Gene Aliases: -
• Location: Chr.10:129467184-129770983 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MGMT	NM_002412.4			NP_002403.2
	XM_005252682.2			XP_005252739.1
	AK293593.1
	BC000824.1			AAH00824.1
	BI520029.1
	DC387686.1
	DC416206.1
	M29971.1			AAA59596.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1053385	Chr.10:129464651 - 129478805 on Build GRCh38	Loss	MGMT
nsv1054536	Chr.10:128923253 - 129746972 on Build GRCh38	Gain	MGMT
esv3577850	Chr.10:128673756 - 129928631 on Build GRCh38	Gain	MGMT MIR4297 EBF3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

DNA ligation
DNA methylation
DNA dealkylation involved in DNA repair
response to toxic substance
cellular response to oxidative stress
response to drug
negative regulation of apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to ethanol
response to folic acid
mammary gland epithelial cell differentiation
cellular response to organic cyclic compound
cellular response to ionizing radiation
positive regulation of double-strand break repair

Function(s)

DNA binding
damaged DNA binding
methylated-DNA-[protein]-cysteine S-methyltransferase activity
calcium ion binding
methyltransferase activity
DNA-methyltransferase activity