Hs05327872_cn

• Gene Symbol: MAP2K1
• Assay Reference Genome Location: Chr.15:66419182 on build GRCh38
• Cytoband: 15q22.31

Target Gene Details

• Entrez Gene ID: 5604
• Gene Name: mitogen-activated protein kinase kinase 1
• Gene Aliases: CFC3, MAPKK1, MEK1, MKK1, PRKMK1
• Location: Chr.15:66386873-66491544 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MAP2K1	NM_002755.3			NP_002746.1
	XM_011521783.2			XP_011520085.1
	XM_017022411.1			XP_016877900.1
	XM_017022412.1			XP_016877901.1
	AK291500.1
	AK294322.1
	AK312356.1
	BC137459.1
	BC139729.1
	L05624.1			AAA36318.1
	L11284.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833045	Chr.15:66295248 - 66460419 on Build GRCh38	Gain	TIPIN DIS3L MAP2K1 SCARNA14

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPK activity
movement of cell or subcellular component
chemotaxis
cell cycle arrest
signal transduction
heart development
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
peptidyl-tyrosine phosphorylation
cerebellar cortex formation
neuron differentiation
keratinocyte differentiation
thyroid gland development
regulation of stress-activated MAPK cascade
proteolysis in other organism
positive regulation of transcription, DNA-templated
thymus development
regulation of axon regeneration
cell motility
positive regulation of axonogenesis
Bergmann glial cell differentiation
face development
trachea formation
epithelial cell proliferation involved in lung morphogenesis
placenta blood vessel development
labyrinthine layer development
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
positive regulation of protein serine/threonine kinase activity
regulation of Golgi inheritance
cellular senescence
mitophagy in response to mitochondrial depolarization
positive regulation of production of miRNAs involved in gene silencing by miRNA
regulation of early endosome to late endosome transport

Function(s)

protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
receptor signaling protein tyrosine phosphatase activity
protein binding
ATP binding
protein C-terminus binding
protein kinase binding
protein serine/threonine kinase activator activity
protein N-terminus binding