Hs05396535_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67174575 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001185057.2			NP_001171986.1
	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276311.1			NP_001263240.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	NM_003946.6			NP_003937.1
	XM_005256217.2			XP_005256274.1
	XM_005256219.3			XP_005256276.1
	XM_011523424.2			XP_011521726.1
	XM_017023843.1			XP_016879332.1
	AF043244.1			AAC34993.1
	AF064599.1			AAC18593.1
	AF064600.1			AAC18594.1
	AK294145.1
	AK314899.1
	BC012798.2			AAH12798.1
	BP215200.1
	BQ685512.1
	BT020158.1			AAV38960.1
	CB959673.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	CTCF PSMB10 TPPP3 LRRC29 NUTF2 FBXL8 DDX28 LOC107984813 PSKH1 DUS2 TSNAXIP1 ELMO3 CARMIL2 LOC105369155 THAP11 ATP6V0D1 LCAT ZDHHC1 AGRP KIAA0895L KCTD19 CENPT NOL3 TMEM208 LOC100131303 C16orf86 MIR328 HSD11B2 EXOC3L1 SLC9A5 LRRC36 GFOD2 CTRL HSF4 ENKD1 E2F4 PARD6A RANBP10 SLC12A4 DPEP2 TRADD ACD FHOD1 NRN1L DPEP3 PLEKHG4 FAM65A LOC100505942 EDC4
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	HSF4 NOL3 TMEM208 C16orf70 LOC105369155 LRRC29 E2F4 TRADD MIR328 EXOC3L1 FBXL8 FHOD1 KIAA0895L B3GNT9 ELMO3
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	HSF4 NOL3 TMEM208 C16orf70 LOC105369155 LRRC29 E2F4 TRADD MIR328 EXOC3L1 FBXL8 SLC9A5 FHOD1 PLEKHG4 KIAA0895L B3GNT9 ELMO3
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	HSF4 NOL3 EXOC3L1 FBXL8 LOC105369155 LRRC29 E2F4 KIAA0895L ELMO3 MIR328
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	CTCF PSMB10 TPPP3 LRRC29 NUTF2 FBXL8 DDX28 LOC107984813 PSKH1 DUS2 TSNAXIP1 ELMO3 CARMIL2 LOC105369155 THAP11 ATP6V0D1 LCAT ZDHHC1 AGRP KIAA0895L KCTD19 CENPT NOL3 TMEM208 C16orf70 LOC100131303 C16orf86 MIR328 HSD11B2 EXOC3L1 SLC9A5 LRRC36 GFOD2 CTRL HSF4 ENKD1 E2F4 PARD6A RANBP10 SLC12A4 DPEP2 TRADD ACD FHOD1 NRN1L DPEP3 PLEKHG4 FAM65A LOC100505942 B3GNT9 EDC4
nsv471092	Chr.16:67174030 - 67518392 on Build GRCh38	Gain	NOL3 TPPP3 TMEM208 LOC105369155 LRRC29 E2F4 ATP6V0D1 MIR328 HSD11B2 EXOC3L1 ZDHHC1 SLC9A5 FHOD1 LRRC36 AGRP PLEKHG4 KIAA0895L KCTD19 LOC100505942 ELMO3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding