Hs05396872_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67170911 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2	1	89	XP_011521726.1
	AK092623.1	1	364
	AK294145.1
	BP215200.1
	CB959673.1
	DA370107.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	C16orf86 FHOD1 KCTD19 ACD ENKD1 CTRL NOL3 ATP6V0D1 CARMIL2 LOC100131303 SLC9A5 HSD11B2 LOC100505942 TRADD TMEM208 TPPP3 DPEP3 PARD6A DUS2 FBXL8 EXOC3L1 MIR328 KIAA0895L PSMB10 EDC4 TSNAXIP1 LCAT CTCF E2F4 NRN1L HSF4 AGRP LOC105369155 GFOD2 THAP11 FAM65A DDX28 PSKH1 PLEKHG4 LRRC36 ZDHHC1 LRRC29 DPEP2 NUTF2 CENPT RANBP10 LOC107984813 SLC12A4 ELMO3
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	FHOD1 TRADD TMEM208 LRRC29 FBXL8 EXOC3L1 MIR328 NOL3 E2F4 KIAA0895L HSF4 ELMO3 LOC105369155 C16orf70 B3GNT9
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	FHOD1 TRADD TMEM208 PLEKHG4 LRRC29 FBXL8 EXOC3L1 MIR328 NOL3 E2F4 KIAA0895L HSF4 ELMO3 SLC9A5 LOC105369155 C16orf70 B3GNT9
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	NOL3 E2F4 KIAA0895L HSF4 LRRC29 FBXL8 ELMO3 LOC105369155 EXOC3L1 MIR328
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	C16orf86 FHOD1 KCTD19 ACD ENKD1 CTRL NOL3 ATP6V0D1 CARMIL2 LOC100131303 SLC9A5 HSD11B2 LOC100505942 TRADD TMEM208 TPPP3 DPEP3 PARD6A DUS2 FBXL8 EXOC3L1 MIR328 KIAA0895L PSMB10 EDC4 TSNAXIP1 LCAT CTCF E2F4 NRN1L HSF4 AGRP LOC105369155 C16orf70 B3GNT9 GFOD2 THAP11 FAM65A DDX28 PSKH1 PLEKHG4 LRRC36 ZDHHC1 LRRC29 DPEP2 NUTF2 CENPT RANBP10 LOC107984813 SLC12A4 ELMO3

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding