Hs05419331_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67171561 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2			XP_011521726.1
	AK092623.1	1	1014
	AK294145.1
	BP215200.1
	CB959673.1
	DA370107.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	E2F4 ZDHHC1 HSF4 LOC105369155 SLC9A5 LCAT ELMO3 KCTD19 EDC4 EXOC3L1 C16orf86 NRN1L CENPT NUTF2 PARD6A LOC107984813 TPPP3 THAP11 AGRP TSNAXIP1 TRADD ATP6V0D1 LRRC36 RANBP10 SLC12A4 HSD11B2 GFOD2 CTCF DUS2 PLEKHG4 MIR328 NOL3 CARMIL2 LOC100131303 PSMB10 ENKD1 PSKH1 LRRC29 FBXL8 ACD LOC100505942 DPEP2 FAM65A KIAA0895L CTRL FHOD1 DDX28 TMEM208 DPEP3
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	E2F4 FBXL8 HSF4 LOC105369155 ELMO3 KIAA0895L MIR328 NOL3 EXOC3L1 FHOD1 TMEM208 B3GNT9 TRADD C16orf70 LRRC29
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	E2F4 FBXL8 HSF4 LOC105369155 SLC9A5 ELMO3 KIAA0895L PLEKHG4 MIR328 NOL3 EXOC3L1 FHOD1 TMEM208 B3GNT9 TRADD C16orf70 LRRC29
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	E2F4 MIR328 NOL3 FBXL8 EXOC3L1 HSF4 LOC105369155 ELMO3 KIAA0895L LRRC29
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	E2F4 ZDHHC1 HSF4 LOC105369155 SLC9A5 LCAT ELMO3 KCTD19 EDC4 EXOC3L1 C16orf86 NRN1L CENPT B3GNT9 NUTF2 PARD6A LOC107984813 TPPP3 THAP11 AGRP TSNAXIP1 TRADD ATP6V0D1 LRRC36 RANBP10 C16orf70 SLC12A4 HSD11B2 GFOD2 CTCF DUS2 PLEKHG4 MIR328 NOL3 CARMIL2 LOC100131303 PSMB10 ENKD1 PSKH1 LRRC29 FBXL8 ACD LOC100505942 DPEP2 FAM65A KIAA0895L CTRL FHOD1 DDX28 TMEM208 DPEP3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding