Hs05422802_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67172059 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2			XP_011521726.1
	AK092623.1	1	1512
	AK294145.1
	BP215200.1
	CB959673.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	NUTF2 DUS2 LRRC29 SLC12A4 LCAT LOC100131303 NRN1L HSF4 KIAA0895L EDC4 ELMO3 PSKH1 HSD11B2 CARMIL2 PARD6A ATP6V0D1 ACD LRRC36 KCTD19 FAM65A CTCF SLC9A5 CTRL LOC107984813 GFOD2 DDX28 TMEM208 LOC100505942 FBXL8 THAP11 EXOC3L1 ZDHHC1 ENKD1 LOC105369155 FHOD1 PLEKHG4 DPEP2 MIR328 TSNAXIP1 TRADD C16orf86 E2F4 RANBP10 DPEP3 PSMB10 AGRP TPPP3 CENPT NOL3
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	TRADD KIAA0895L C16orf70 TMEM208 E2F4 FBXL8 ELMO3 LRRC29 EXOC3L1 LOC105369155 NOL3 FHOD1 PLEKHG4 HSF4 MIR328 B3GNT9 SLC9A5
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	TRADD KIAA0895L C16orf70 TMEM208 E2F4 FBXL8 ELMO3 LRRC29 EXOC3L1 LOC105369155 NOL3 FHOD1 HSF4 MIR328 B3GNT9
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	EXOC3L1 KIAA0895L LOC105369155 NOL3 E2F4 FBXL8 ELMO3 HSF4 MIR328 LRRC29
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	NUTF2 DUS2 LRRC29 SLC12A4 LCAT LOC100131303 NRN1L HSF4 KIAA0895L EDC4 ELMO3 PSKH1 HSD11B2 CARMIL2 PARD6A ATP6V0D1 ACD LRRC36 KCTD19 FAM65A CTCF SLC9A5 CTRL LOC107984813 GFOD2 DDX28 TMEM208 LOC100505942 FBXL8 THAP11 EXOC3L1 ZDHHC1 ENKD1 LOC105369155 FHOD1 PLEKHG4 DPEP2 MIR328 TSNAXIP1 TRADD C16orf86 C16orf70 E2F4 RANBP10 DPEP3 PSMB10 AGRP TPPP3 CENPT NOL3 B3GNT9

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding