Hs05422802_cn

• Gene Symbol: NOL3
• Assay Reference Genome Location: Chr.16:67172059 on build GRCh38
• Cytoband: 16q22.1

Target Gene Details

• Entrez Gene ID: 8996
• Gene Name: nucleolar protein 3
• Gene Aliases: ARC, FCM, MYP, NOP, NOP30
• Location: Chr.16:67170497-67175737 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOL3	NM_001276307.1			NP_001263236.1
	NM_001276309.1			NP_001263238.1
	NM_001276312.1			NP_001263241.1
	NM_001276319.1			NP_001263248.1
	XM_011523424.2			XP_011521726.1
	AK092623.1	1	1512
	AK294145.1
	BP215200.1
	CB959673.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv522852	Chr.16:67153308 - 68071571 on Build GRCh38	Gain	DDX28 TSNAXIP1 HSD11B2 CENPT LCAT TRADD LRRC29 FAM65A PSMB10 EDC4 FBXL8 DPEP3 KIAA0895L RANBP10 THAP11 ZDHHC1 CTRL FHOD1 DPEP2 KCTD19 SLC9A5 ENKD1 LOC100505942 SLC12A4 HSF4 ACD ATP6V0D1 CARMIL2 EXOC3L1 MIR328 E2F4 PSKH1 LOC100131303 TMEM208 PARD6A ELMO3 GFOD2 AGRP C16orf86 NOL3 LOC107984813 CTCF TPPP3 LRRC36 NRN1L LOC105369155 DUS2 NUTF2 PLEKHG4
nsv952044	Chr.16:67141198 - 67244397 on Build GRCh38	Deletion	KIAA0895L HSF4 NOL3 B3GNT9 FHOD1 TRADD LRRC29 EXOC3L1 MIR328 E2F4 C16orf70 LOC105369155 FBXL8 TMEM208 ELMO3
nsv827707	Chr.16:67148355 - 67289296 on Build GRCh38	Loss	KIAA0895L HSF4 NOL3 B3GNT9 FHOD1 TRADD LRRC29 EXOC3L1 MIR328 E2F4 C16orf70 LOC105369155 FBXL8 SLC9A5 TMEM208 ELMO3 PLEKHG4
nsv1160429	Chr.16:67161549 - 67220197 on Build GRCh38	Deletion	KIAA0895L LRRC29 EXOC3L1 MIR328 E2F4 LOC105369155 FBXL8 HSF4 NOL3 ELMO3
nsv524363	Chr.16:67136529 - 68071571 on Build GRCh38	Loss	DDX28 TSNAXIP1 HSD11B2 CENPT B3GNT9 LCAT TRADD LRRC29 FAM65A C16orf70 PSMB10 EDC4 FBXL8 DPEP3 KIAA0895L RANBP10 THAP11 ZDHHC1 CTRL FHOD1 DPEP2 KCTD19 SLC9A5 ENKD1 LOC100505942 SLC12A4 HSF4 ACD ATP6V0D1 CARMIL2 EXOC3L1 MIR328 E2F4 PSKH1 LOC100131303 TMEM208 PARD6A ELMO3 GFOD2 AGRP C16orf86 NOL3 LOC107984813 CTCF TPPP3 LRRC36 NRN1L LOC105369155 DUS2 NUTF2 PLEKHG4

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

response to hypoxia
blood vessel remodeling
response to ischemia
mRNA splice site selection
RNA splicing
cardiac muscle cell apoptotic process
negative regulation of cardiac muscle cell apoptotic process
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of muscle atrophy
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to injury involved in regulation of muscle adaptation
regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
protein oligomerization
negative regulation of necrotic cell death
negative regulation of release of cytochrome c from mitochondria
intrinsic apoptotic signaling pathway
negative regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

RNA binding
death receptor binding
calcium ion binding
protein binding
death effector domain binding
identical protein binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
caspase binding