Hs05486933_cn

• Gene Symbol: PRKCA
• Assay Reference Genome Location: Chr.17:66415482 on build GRCh38
• Cytoband: 17q24.2

Target Gene Details

• Entrez Gene ID: 5578
• Gene Name: protein kinase C alpha
• Gene Aliases: AAG6, PKC-alpha, PKCA, PRKACA
• Location: Chr.17:66302640-66810744 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRKCA	NM_002737.2			NP_002728.1
	XM_017024836.1			XP_016880325.1
	XM_017024841.1			XP_016880330.1
	AB209475.1			BAD92712.1
	AB451258.1
	AB451383.1
	AY633609.1			AAV33302.1
	BC053321.1			AAH53321.1
	BC109273.1			AAI09274.1
	BC109274.1			AAI09275.1
	LC151409.1
	M22199.1			AAA60098.1
	X52479.1			CAA36718.1

Target Gene Details

• Entrez Gene ID: 101928001
• Gene Name: PRKCA antisense RNA 1
• Gene Aliases: -
• Location: Chr.17:66398069-66416854 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PRKCA-AS1	NR_110822.1	2	616

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3582875	Chr.17:66413661 - 66485920 on Build GRCh38	Loss	PRKCA PRKCA-AS1
esv3582876	Chr.17:66415296 - 66431745 on Build GRCh38	Loss	PRKCA PRKCA-AS1
nsv457881	Chr.17:66412731 - 66435948 on Build GRCh38	Loss	PRKCA PRKCA-AS1
nsv833520	Chr.17:66261176 - 66438257 on Build GRCh38	Gain	PRKCA PRKCA-AS1
nsv575896	Chr.17:66414797 - 66475557 on Build GRCh38	Loss	PRKCA PRKCA-AS1
nsv1064970	Chr.17:66414666 - 66490150 on Build GRCh38	Loss	PRKCA PRKCA-AS1

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

angiogenesis
positive regulation of endothelial cell proliferation
desmosome assembly
protein phosphorylation
mitotic nuclear envelope disassembly
cell adhesion
activation of adenylate cyclase activity
negative regulation of adenylate cyclase activity
positive regulation of endothelial cell migration
positive regulation of cardiac muscle hypertrophy
peptidyl-serine phosphorylation
platelet activation
positive regulation of cell migration
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of glial cell apoptotic process
histone H3-T6 phosphorylation
intracellular signal transduction
regulation of mRNA stability
positive regulation of blood vessel endothelial cell migration
positive regulation of macrophage differentiation
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of mitotic cell cycle
regulation of insulin secretion
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
regulation of platelet aggregation
apoptotic signaling pathway
positive regulation of dense core granule biogenesis

Function(s)

protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein binding
ATP binding
zinc ion binding
enzyme binding
histone kinase activity (H3-T6 specific)