Hs05578464_cn

• Gene Symbol: GRK3
• Assay Reference Genome Location: Chr.22:25596661 on build GRCh38
• Cytoband: 22q12.1

Target Gene Details

• Entrez Gene ID: 157
• Gene Name: G protein-coupled receptor kinase 3
• Gene Aliases: ADRBK2, BARK2
• Location: Chr.22:25564894-25729294 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GRK3	NM_005160.3			NP_005151.2
	AK058103.1
	AK292234.1
	AK310398.1
	BC036797.1			AAH36797.1
	BX387339.2
	X69117.1			CAA48870.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1066595	Chr.22:25596614 - 26071416 on Build GRCh38	Gain	MYO18B GRK3
nsv517205	Chr.22:25244661 - 25629591 on Build GRCh38	Gain+Loss	CRYBB2P1 IGLL3P LOC100652901 LRP5L LOC105372969 MIR6817 GRK3 LOC105372966
nsv471189	Chr.22:25254438 - 25598046 on Build GRCh38	Gain	CRYBB2P1 IGLL3P LOC100652901 LRP5L LOC105372969 MIR6817 GRK3 LOC105372966
dgv4554n100	Chr.22:25308251 - 25608716 on Build GRCh38	Loss	CRYBB2P1 IGLL3P LOC100652901 LRP5L MIR6817 GRK3 LOC105372966
nsv1058343	Chr.22:25507736 - 25642811 on Build GRCh38	Loss	GRK3
esv2758829	Chr.22:24970834 - 25650546 on Build GRCh38	Gain+Loss	CRYBB2P1 LOC100128531 IGLL3P LOC100652901 LRP5L CRYBB2 KIAA1671 LOC105372969 MIR6817 CRYBB3 GRK3 LOC105372966
esv2751952	Chr.22:25262579 - 25754679 on Build GRCh38	Gain	CRYBB2P1 IGLL3P LOC100652901 LRP5L MYO18B LOC105372969 MIR6817 GRK3 LOC105372966
dgv100e203	Chr.22:25232032 - 25612136 on Build GRCh38	Gain+Loss	CRYBB2P1 IGLL3P LOC100652901 LRP5L LOC105372969 MIR6817 GRK3 LOC105372966
nsv469691	Chr.22:25457547 - 25622123 on Build GRCh38	Gain+Loss	CRYBB2P1 GRK3 LOC105372966
dgv4550n100	Chr.22:25265409 - 25608716 on Build GRCh38	Gain	CRYBB2P1 IGLL3P LOC100652901 LRP5L LOC105372969 MIR6817 GRK3 LOC105372966
nsv471598	Chr.22:25457548 - 25622123 on Build GRCh38	Gain+Loss	CRYBB2P1 GRK3 LOC105372966

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

protein phosphorylation
signal transduction
receptor internalization

Function(s)

protein kinase activity
G-protein coupled receptor kinase activity
ATP binding
beta-adrenergic receptor kinase activity