Hs06128119_cn

• Gene Symbol: GDNF
• Assay Reference Genome Location: Chr.5:37838252 on build GRCh38
• Cytoband: 5p13.2

Target Gene Details

• Entrez Gene ID: 2668
• Gene Name: glial cell derived neurotrophic factor
• Gene Aliases: ATF1, ATF2, HFB1-GDNF, HSCR3
• Location: Chr.5:37812677-37840044 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
GDNF	NM_000514.3			NP_000505.1
	XM_011514030.2			XP_011512332.1
	XM_017009337.1			XP_016864826.1
	AF053748.1			AAD43139.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv1593e212	Chr.5:37832461 - 37848988 on Build GRCh38	Loss	GDNF-AS1 GDNF
esv3604748	Chr.5:37720912 - 37848930 on Build GRCh38	Gain	WDR70 GDNF-AS1 GDNF

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

neurotrophic factor

Gene Ontology Categories:

Process(es)

MAPK cascade
metanephros development
branching involved in ureteric bud morphogenesis
neural crest cell migration
organ induction
postsynaptic membrane organization
mesenchymal to epithelial transition involved in metanephros morphogenesis
signal transduction
nervous system development
positive regulation of cell proliferation
adult locomotory behavior
regulation of gene expression
postganglionic parasympathetic fiber development
peristalsis
neuron projection development
positive regulation of monooxygenase activity
positive regulation of dopamine secretion
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mRNA stabilization
enteric nervous system development
sympathetic nervous system development
regulation of dopamine uptake involved in synaptic transmission
ureteric bud formation
regulation of morphogenesis of a branching structure
positive regulation of ureteric bud formation
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
positive regulation of branching involved in ureteric bud morphogenesis
regulation of stem cell differentiation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Function(s)

Ras guanyl-nucleotide exchange factor activity
receptor binding
protein binding
growth factor activity
protein homodimerization activity