Hs07059035_cn

• Gene Symbol: ARHGEF40
• Assay Reference Genome Location: Chr.14:21066190 on build GRCh38
• Cytoband: 14q11.2

Target Gene Details

• Entrez Gene ID: 55701
• Gene Name: Rho guanine nucleotide exchange factor 40
• Gene Aliases: SOLO
• Location: Chr.14:21061276-21090248 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARHGEF40	XM_017021434.1			XP_016876923.1

Target Gene Details

• Entrez Gene ID: 57447
• Gene Name: NDRG family member 2
• Gene Aliases: SYLD
• Location: Chr.14:21016763-21070872 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NDRG2	NM_001282211.1			NP_001269140.1
	AK293514.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv826882	Chr.14:21042862 - 21136042 on Build GRCh38	Gain	RNASE8 TMEM253 ZNF219 RNASE7 NDRG2 ARHGEF40
nsv832740	Chr.14:20863901 - 21076893 on Build GRCh38	Gain	TPPP2 METTL17 RNASE8 ECRP LOC101929718 SLC39A2 RNASE13 RNASE3 RNASE2 RNASE7 MIR6717 NDRG2 ARHGEF40

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor, serine protease

Gene Ontology Categories:

Process(es)

regulation of Rho protein signal transduction
positive regulation of GTPase activity
negative regulation of cytokine production
signal transduction
regulation of vascular endothelial growth factor production
Wnt signaling pathway
substantia nigra development
cell differentiation
negative regulation of smooth muscle cell proliferation
negative regulation of ERK1 and ERK2 cascade
regulation of platelet-derived growth factor production

Function(s)

Rho guanyl-nucleotide exchange factor activity
molecular_function
protein binding