Mm00365008_cn

• Gene Symbol: Top2a
• Assay Reference Genome Location: Chr.11:99003565 on build GRCm38
• Cytoband: 11D

Target Gene Details

• Entrez Gene ID: 21973
• Gene Name: topoisomerase (DNA) II alpha
• Gene Aliases: Top-2
• Location: Chr.11:98992947-99024206 on Build GRCm38
• Assay Gene Location: Within Exon 23

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
Top2a	NM_011623.2	23	3062	NP_035753.2
	AK033321.1	11	1444	BAC28232.1
	AK161381.1	3	375	BAE36361.1
	AK169723.1	8	1074
	D12513.1	23	2988	BAA02076.1

More Information

• Set Membership: Intragenic, Exonic

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

resolution of meiotic recombination intermediates
sister chromatid segregation
hematopoietic progenitor cell differentiation
DNA metabolic process
DNA topological change
DNA ligation
DNA unwinding involved in DNA replication
cellular response to DNA damage stimulus
chromosome segregation
chromosome condensation
apoptotic chromosome condensation
embryonic cleavage
regulation of circadian rhythm
positive regulation of apoptotic process
mitotic DNA integrity checkpoint
positive regulation of viral genome replication
positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
positive regulation of transcription from RNA polymerase II promoter
rhythmic process

Function(s)

nucleotide binding
magnesium ion binding
DNA binding
chromatin binding
DNA topoisomerase activity
DNA topoisomerase type II (ATP-hydrolyzing) activity
protein kinase C binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
drug binding
DNA binding, bending
isomerase activity
enzyme binding
protein homodimerization activity
histone deacetylase binding
ubiquitin binding
sequence-specific DNA binding
structure-specific DNA binding
poly(A) RNA binding
metal ion binding
protein heterodimerization activity