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Medchemexpress LLC [1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]- | 1802637-39-3 | 98.19% | 459.97 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY111347

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BB-Cl-Amidine is identified as a peptidylarginine deiminase (PAD) inhibitor. It is intended for research use only and not for sale to patients.

  • Acts as an inhibitor of peptidylarginine deiminase (PAD).
  • Demonstrated cytotoxicity against human U2OS cells with an EC50 of 8.8 μM after 72 hours by XTT assay, and an IC50 of 8.8 μM after 72 hours by MTT assay.
  • In MRL/lpr mice, treatment subtly reduces splenomegaly, shows a trend towards increased circulating levels of anti-NET antibodies, and significantly improves endothelium-dependent vasorelaxation.
  • Also shows a strong trend towards downregulation of IRGs and significantly improves muzzle alopecia.

Catalog No. 50-003-46769


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