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Medchemexpress LLC 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380) | 1627138-52-6 | 99.9% | 494.53 g/mol | C23H25F3N4O3S | 50MG
SDP

Supplier:  Medchemexpress LLC HY1243950MG

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ML380 is a potent, subtype-selective, brain-penetrant positive allosteric modulator (PAM) of the M5 muscarinic acetylcholine receptor (mAChR), reported with EC50 ≈190 nM (human) and ≈610 nM (rat). It is supplied for preclinical pharmacology and neuroscience research; molecular formula C23H25F3N4O3S, molecular weight 494.53 g/mol.

  • Potent M5 positive allosteric modulator (EC50 ≈190 nM human).
  • Moderate selectivity versus M1 and M3 subtypes.
  • Brain-penetrant profile suitable for CNS studies.
  • High purity (99.87%) for reliable experimental use.
  • Soluble in DMSO at 100 mg/mL for formulation and dosing.
  • Available in multiple vial sizes to support in vitro and in vivo studies.

Catalog No. 50-002-37305


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