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Medchemexpress LLC 1-((1H-indazol-5-yl)sulfonyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide | 1627138-52-6 | >99.0% | 494.53 g/mol | C23H25F3N4O3S | 100MG
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Supplier:  Medchemexpress LLC HY12439100MG

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ML380 is a potent, brain-penetrant positive allosteric modulator (PAM) of the M5 muscarinic acetylcholine receptor used in research on GPCR signaling and neuronal function. It increases acetylcholine affinity at M5 and displays subtype selectivity (EC50 human ≈190 nM; rat ≈610 nM). CAS: 1627138-52-6.

  • Potent positive allosteric modulator of M5 mAChR.
  • Subtype-selective with moderate selectivity over M1 and M3.
  • Brain-penetrant, suitable for in vivo pharmacology studies.
  • High purity (>99.0% by HPLC).
  • Molecular formula C23H25F3N4O3S; molecular weight 494.53 g/mol.
  • Supplied as a 100 mg solid for research use only.

Catalog No. 50-002-36330


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