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Cayman Chemical 1- 2 6-Xylyl-2-thIourea 50mg
Supplier: Cayman Chemical 3937350 MG
An inhibitor of Cdk2 and Cdk9 (IC50s 4.5 and 20.5 nM respectively) selective for Cdk2 and Cdk9 over Cdk1 -4 and -7 (IC50s 278 193 and 232 nM respectively) inhibits the proliferation of COLO 205 cells (IC50 0.31 UM) inhibits proliferation in a panel of five breast cancer cell lines (IC50s 0.4 UM for all) decreases phosphorylation of the RNA polymerase II C-terminal domain and RB and induces apoptosis in COLO 205 cells reduces tumor volume in an EoL-1 mouse xenograft model at 40 and 55 mg/kg inhibits tumor growth in an HL-60 mouse xenograft model at 70 mg/kg
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