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Medchemexpress LLC 1,2-Benzisothiazol-3-amine, N-[2-(1-pyrrolidinyl)phenyl]-, 1,1-dioxide | 874590-32-6 | 99.5% | 327.40 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY11154710MM/1ML

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M1001 is a weak hypoxia-inducible factor-2α (HIF-2α) agonist that binds to the HIF-2α PAS-B domain with a Kd of 667 nM. It can be used in chronic kidney disease research, increasing the expression of HIF-2 target genes modestly in 786-O cells and reducing the physical association between HIF-2α and VHL in HEK293T cells.

  • Target: HIF-2α.
  • Kd: 667 nM (HIF-2α).
  • Appearance: Solid, light green to green.
  • Solubility in DMSO: 250 mg/mL (763.59 mM); requires ultrasonic.
  • Solubility in vivo: ≥ 2.33 mg/mL (7.12 mM) in 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline.
  • Powder storage: -20°C for 3 years, 4°C for 2 years.
  • In-solvent storage: -80°C for 2 years, -20°C for 1 year.
  • Increases expression of HIF-2 target genes in 786-O cells.
  • Reduces the physical association between HIF-2α and VHL in HEK293T cells.

Catalog No. 50-003-47480


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