Cayman Chemical 1 2bIs heptnoylthIo GlycR 50mg

Supplier:  Cayman Chemical 6223550 MG

A p62 antagonist (IC50 31.18 nM for the human receptor) decreases the soluble fraction of p62 in MM.1S cells at1.5 UM increases the levels of polyubiquitinated proteins in MM.1S cells at 200 nM induces apoptosis in MM.1S at 100 nM decreases the survival of CD138 cells but not CD138- cells in primary plasma cells derived from patients with multiple myeloma at 50 to 400 nM reduces the viability of tumor tissue samples isolated from ten PDX mouse models of colorectal cancer (IC50s 113-1220 nM) reduces tumor volume in an HCT116 mouse xenograft model at 8 or 12 mg/kg twice per week

Catalog No. 50-289-3560