Cayman Chemical 1 2DIoleoyl3dImethylamonI 10mg

Supplier:  Cayman Chemical 2572610 MG

An agonist of a1- and a2-ARs (Kds 6 320 and 390 nM for a1A- a1B- and a1D-ARs respectively Ki 15 nM for a2-AR) acts as an agonist of 5-HT1 receptors (Kds 4.68 25.7 5.01 nM for 5-HT1A 5-HT1B and 5-HT1D respectively) increases intracellular calcium levels in CHO cells transfected with the a1A-AR (EC50 40.7 nM) acts as a partial agonist of the a2-AR in perfused rat heart (IC50 63 nM and EC50 13.5 nM for norepinephrine release) acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin and clonidine respectively (Kds 110 and 257 nM respectively) inhibits forskolin-stimulated adenylate cyclase activity (EC50s 18.6 24.0 and 44.7 nM in tissues expressing high levels of 5-HT1A 5-HT1B and 5-HT1D receptors respectively) and accumulation of inositol phosphates (EC50 269 nM in pig choroid plexus preparations which highly express 5-HT1C receptors) decreases nasal pressure in dogs by 6.9 when used at a dose of 0.2 g/kg

Catalog No. 50-293-6050